Prostin VR Pediatric Side Effects

Generic Name: alprostadil

Note: This page contains side effects data for the generic drug alprostadil. It is possible that some of the dosage forms included below may not apply to the brand name Prostin VR Pediatric.

It is possible that some side effects of Prostin VR Pediatric may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to alprostadil: kit, powder for solution, solution, suppository

As well as its needed effects, alprostadil (the active ingredient contained in Prostin VR Pediatric) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking alprostadil, check with your doctor immediately:

Rare
  • Curving of penis with pain during erection
  • erection continuing for 4 to 6 hours
  • erection continuing longer than 6 hours with severe and continuing pain of the penis
  • swelling in or pain of the testes
Symptoms of too much medicine being absorbed into the body
  • Dizziness
  • faintness
  • pelvic pain
  • flu-like symptoms

Some alprostadil side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Bleeding at place of injection, short-term
  • mild bleeding or spotting from urethra (suppository only)
  • pain at place of injection
  • painful erection
  • stinging of urethra (suppository only)
Rare

Female partners may experience itching or stinging of vagina when you first begin using the alprostadil suppository. These side effects may not be caused from the medicine but may result if female partner has not had frequent or recent sexual intercourse.

  • Bruising or clotted blood in penis at place of injection, usually caused by an incorrect injection

For Healthcare Professionals

Applies to alprostadil: compounding powder, injectable kit, injectable powder for injection, injectable solution, transurethral suppository

Local

Local side effects have included penile pain (37%), prolonged erection (4%), penile fibrosis (3%), injection site hematoma (3%), penis disorder (3%), injection site ecchymosis (2%), penile rash (1%), penile edema (1%), balanitis, injection site hemorrhage, injection site inflammation, injection site itching, injection site swelling and edema, urethral bleeding, penile warmth, numbness, yeast infection, irritation, sensitivity, phimosis, pruritus, erythema, venous leak, painful erection, and abnormal ejaculation. Postmarketing experience has included reports of needle breakage.

Cardiovascular

Hemodynamic changes manifested as hypotension and increases in pulse rate were generally observed at doses above 20 mcg and 30 mcg respectively, and appeared to be dose-dependent. These changes were usually reported as clinically unimportant, and only three patients discontinued treatment because of symptomatic hypotension.

Cardiovascular side effects have included hypertension (2%), hypotension, vasodilation, peripheral vascular disorder, supraventricular extrasystoles, vasovagal reactions, and increases in pulse rate.

Nervous system

Nervous system side effects have included headache (2%), dizziness (1%), hypesthesia, and non-generalized weakness.

Musculoskeletal

Musculoskeletal side effects have included back pain (1%) and leg cramps.

Respiratory

Respiratory side effects have included upper respiratory infection (4%), flu syndrome (2%), sinusitis (2%), nasal congestion (1%), and cough (1%).

Genitourinary

Genitourinary side effects have included prostatic disorder (2%), testicular pain, scrotal disorder, scrotal edema, hematuria, testicular disorder, impaired urination, urinary frequency, urinary urgency, and pelvic pain.

Ocular

Ocular side effects have included mydriasis.

Gastrointestinal

Gastrointestinal side effects have rarely included nausea and dry mouth.

Other

Other side effects have included localized pain (2%), trauma (2%), diaphoresis, rash, non-application site pruritus, skin neoplasm, and increased serum creatinine.
Postmarketing reports: Device malfunction/failure

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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