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Levocabastine ophthalmic Side Effects

For the Consumer

Applies to levocabastine ophthalmic: ophthalmic suspension

In addition to its needed effects, some unwanted effects may be caused by levocabastine ophthalmic. In the event that any of these side effects do occur, they may require medical attention.

Severity: Moderate

If any of the following side effects occur while taking levocabastine ophthalmic, check with your doctor or nurse as soon as possible:

Less common:
  • Headache
  • Change in vision or trouble in seeing
  • cough
  • eye pain
  • nausea
  • redness, tearing, discharge, or other eye irritation not present before therapy or becoming worse during therapy
  • skin rash
  • sore throat
  • swelling of eyelids
  • troubled breathing
  • unusual tiredness or weakness

Severity: Minor

Some of the side effects that can occur with levocabastine ophthalmic may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Burning or stinging when medicine is applied
Less common:
  • Dry eyes
  • dry mouth
  • feeling sleepy

For Healthcare Professionals

Applies to levocabastine ophthalmic: ophthalmic suspension


In general, levocabastine is very well tolerated with minimal adverse effects. Most studies have indicated that the percent of adverse reactions with levocabastine occur with similar frequency on placebo. Local mild, transient stinging and burning appear to be the most common adverse effect occurring in approximately 25% of patients. Adverse effects do not appear to be dose-related.[Ref]

Nervous system

Nervous system adverse effects have included headache (5%), dry mouth, fatigue, and somnolence.[Ref]


Ocular side effects have included stinging, burning, visual disturbances, eye pain, eye dryness, red eyes, eyelid edema, lacrimation, and eye discharge.[Ref]


Gastrointestinal side effects have included nausea.[Ref]


Respiratory side effects have included dyspnea, pharyngitis, and cough.[Ref]


Dermatologic side effects have included rash and erythema.[Ref]


1. Dechant KL, Goa KL "Levocabastine. A review of its pharmacological properties and therapeutic potential as a topical antihistamine in allergic rhinitis and conjunctivitis." Drugs 41 (1991): 202-24

2. "Product Information. Livostin (levocabastine)." Ciba Vision Ophthalmics, Duluth, GA.

3. Rombaut N, Bhatti JZ, Curran S, Hindmarch I "Effects of topical administration of levocabastine on psychomotor and cognitive function." Ann Allergy 67 (1991): 75-9

4. Knight A "The role of levocabastine in the treatment of allergic rhinoconjunctivitis." Br J Clin Pract 48 (1994): 139-43

5. Bahmer FA "Topical levocabastine - an effective alternative to oral antihistamines in seasonal allergic rhinoconjunctivitis." Clin Exp Allergy 25 (1995): 220-7

Not all side effects for levocabastine ophthalmic may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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