LetibotulinumtoxinA Side Effects

Applies to letibotulinumtoxinA: intramuscular powder for injection.

General

The most common adverse reaction occurring in more than 2% of patients was headache. Adverse reactions may occur within the first few days following injection and may have a transient duration of up to several months or longer.^[Ref]

Dermatologic

Rare (0.01% to 0.1%): Brow ptosis/heaviness, dry skin, urticaria, folliculitis

Gastrointestinal

Rare (0.01% to 0.1%): Constipation, nausea, oral herpes

Frequency not reported: Dysphagia

Immunologic

Uncommon (0.1% to 1%): Anti-drug antibodies

Local

Common (1% to 10%): Injection site reaction

Uncommon (0.1% to 1%): Injection site: Pain, pressure, bruising, swelling, pruritus, mass

Rare (0.01% to 0.1%): Folliculitis, periorbital hematoma, contusion

Frequency not reported: Injection site: Nodule, inflammation, tenderness, erythema, itching, bleeding

Metabolic

Rare (0.01% to 0.1%): Increased serum potassium

Musculoskeletal

Frequency not reported: Local muscle weakness (expected due to pharmacological action of botulinum toxin in muscle tissue)

Ocular

Uncommon (0.1% to 1%): Eyelid ptosis, blepharospasm, periorbital edema

Rare (0.01% to 0.1%): Conjunctival hemorrhage, dry eye, eye pain

Respiratory

Common (1% to 10%): Nasopharyngitis, bronchitis

Rare (0.01% to 0.1%): Pharyngeal hypoesthesia, streptococcal pharyngitis, pneumonia, sinusitis

Nervous system

Common (1% to 10%): Headache

Uncommon (0.1% to 1%): Head discomfort

Rare (0.01% to 0.1%): Migraine, dizziness, paresthesia, visual field defect

Frequency not reported: Procedural headache

Frequently asked questions

• What is botulinum toxin used to treat?

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer