Lamprene Side Effects

Generic name: clofazimine

Medically reviewed by Drugs.com. Last updated on Jul 15, 2024.

Note: This document provides detailed information about Lamprene.

Applies to clofazimine: oral capsules Side Effects associated with clofazimine. Some dosage forms listed on this page may not apply specifically to the brand name Lamprene.

Applies to clofazimine: oral capsules.

Side effects include:

Discoloration of skin, eyes, urine, feces, sputum, sweat, tears; GI effects (abdominal and epigastric pain, diarrhea, nausea, vomiting, GI intolerance); eye irritation, itching, dryness, burning.

For healthcare professionals

Applies to clofazimine: oral capsule.

General

The most common adverse reactions reported in 40% to 50% of patients included skin and body fluid discoloration, abdominal and epigastric pain, diarrhea, nausea, vomiting, and gastrointestinal intolerance.^[Ref]

Cardiovascular

• Frequency not reported: Thromboembolism, vascular pain, QT prolongation

Dermatologic

• Very common (10% or more): Skin discoloration (up to 100%), ichthyosis (up to 28%), dryness (up to 28%), rash (up to 5%), pruritus (up to 5%)
• Frequency not reported: Phototoxicity, erythroderma, acneiform eruptions, monilial cheilosis

Gastrointestinal

• Very common (10% or more): Gastrointestinal intolerance (up to 50%), abdominal/epigastric pain (up to 50%), diarrhea (up to 50%), nausea (up to 50%), vomiting (up to 50%)
• Frequency not reported: Abdominal/bowel obstruction, abdominal/epigastric pain, diarrhea, nausea, vomiting, bowel obstruction, gastrointestinal bleeding, constipation, eosinophilic enteritis

Hematologic

• Frequency not reported: Elevated erythrocyte sedimentation rate, elevated albumin, eosinophilia, anemia

Hepatic

• Frequency not reported: Elevated serum bilirubin, elevated AST, hepatitis, jaundice, enlarged liver

Metabolic

• Frequency not reported: Elevated blood sugar, hypokalemia, edema

Musculoskeletal

• Frequency not reported: Bone pain

Nervous system

• Frequency not reported: Dizziness, drowsiness, headache, neuralgia, taste disorder

Ocular

• Frequency not reported: Diminished vision, conjunctival and corneal pigmentation due to clofazimine (the active ingredient contained in Lamprene) crystal deposits, dryness, burning, itching, irritation, maculopathy (bull's eye retinopathy)

Other

• Frequency not reported: Discoloration of urine, feces, sputum, and sweat, splenic infarction, fever, lymphadenopathy, anorexia, weight loss, fatigue, giddiness

Psychiatric

• Frequency not reported: Depression and suicide secondary to skin discoloration

Renal

• Frequency not reported: Cystitis

Further information

Lamprene side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer