Hemgenix Side Effects

Generic name: etranacogene dezaparvovec

Medically reviewed by Drugs.com. Last updated on Mar 26, 2023.

Note: This document contains side effect information about etranacogene dezaparvovec. Some dosage forms listed on this page may not apply to the brand name Hemgenix.

Applies to etranacogene dezaparvovec: intravenous suspension.

Serious side effects of Hemgenix

Along with its needed effects, etranacogene dezaparvovec (the active ingredient contained in Hemgenix) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking etranacogene dezaparvovec:

More common

• Dizziness
• facial swelling
• fever or chills
• headache
• nausea or vomiting
• skin rash
• trouble breathing
• weakness

Less common

• Chest discomfort or tightness
• fast, pounding, or irregular heartbeat or pulse
• hives, itching
• irritation
• joint pain, stiffness, or swelling
• redness or the skin
• swelling of the eyelids, face, lips, hands, or feet

Other side effects of Hemgenix

Some side effects of etranacogene dezaparvovec may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Cough
• diarrhea
• general feeling of discomfort or illness
• loss of appetite
• muscle aches and pains
• runny nose
• shivering
• sore throat
• sweating
• trouble sleeping
• unusual tiredness or weakness

Less common

• Stomach pain

For Healthcare Professionals

Applies to etranacogene dezaparvovec: intravenous suspension.

Gastrointestinal

Common (1% to 10%): Nausea^[Ref]

General

The most common adverse reactions reported were alanine amino transaminase (ALT) elevations, headache, blood creatine kinase elevations, flu-like symptoms, infusion-related reactions, fatigue, malaise, and aspartate transaminase (AST) elevations.^[Ref]

Hepatic

Very common (10% or more): Elevated ALT (42%), elevated AST (42%)^[Ref]

Hypersensitivity

Very common (10% or more): Infusion-related reactions (33%)

Common (1% to 10%): Hypersensitivity^[Ref]

Local

Very common (10% or more): Malaise (12%)^[Ref]

Musculoskeletal

Very common (10% or more): Increased blood creatine kinase (42%)

Other

Very common (10% or more): Fatigue (12%), flu-like symptoms (14%)^[Ref]

Nervous system

Very common (10% or more): Headache (18%)^[Ref]

Frequently asked questions

• Why is Hemgenix the most expensive drug in the world?

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer