Elspar Side Effects

Generic Name: asparaginase escherichia coli

Note: This page contains information about the side effects of asparaginase escherichia coli. Some of the dosage forms included on this document may not apply to the brand name Elspar.

Not all side effects for Elspar may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to asparaginase escherichia coli: injection powder for solution

In addition to its needed effects, some unwanted effects may be caused by asparaginase escherichia coli (the active ingredient contained in Elspar). In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking asparaginase escherichia coli, check with your doctor or nurse immediately:

More common
  • Abdominal or stomach pain
  • bloating
  • blurred vision
  • chills
  • constipation
  • cough
  • darkened urine
  • difficulty with swallowing
  • dizziness
  • dry mouth
  • fast heartbeat
  • fever
  • flushed, dry skin
  • fruit-like breath odor
  • hives
  • increased hunger
  • increased thirst
  • increased urination
  • indigestion
  • itching
  • joint pain
  • loss of appetite
  • nausea
  • pains in the chest, groin, or legs, especially calves of the legs
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • shortness of breath
  • skin rash
  • stomach pain (severe) with nausea and vomiting
  • sudden loss of coordination
  • sudden onset of severe headaches
  • sudden onset of slurred speech
  • sudden vision changes
  • sweating
  • tightness in the chest
  • troubled breathing
  • unexplained weight loss
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting
  • yellow eyes or skin
Less common
  • Confusion
  • convulsions (seizures)
  • depression
  • drowsiness
  • frequent urination
  • loss of bladder control
  • lower back or side pain
  • muscle spasm or jerking of all extremities
  • nervousness
  • numbness or tingling in the hands, arms, or legs
  • seeing, hearing, or feeling things that are not there
  • severe weakness
  • sores in the mouth or on the lips
  • sudden loss of consciousness
  • swelling of the feet or lower legs
  • unusual thirst
Rare
  • Inability to move the arms or legs
Incidence not known
  • Abdominal or stomach tenderness
  • bloody or cloudy urine
  • change in consciousness
  • clay-colored stools
  • continuous nausea or vomiting
  • loss of consciousness
  • pounding in the ears
  • slow heartbeat

Some of the side effects that can occur with asparaginase escherichia coli may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Stomach cramps
  • weight loss

For Healthcare Professionals

Applies to asparaginase escherichia coli: injectable powder for injection

Hematologic

Hematologic side effects have included a marked decrease in circulating lymphoblasts, with normal or below normal leukocyte counts, within the first days after initiating therapy. This is sometimes accompanied by a marked rise in serum uric acid. Pre-renal azotemia has also been reported.

Hypofibrinogenemia has been reported. Depression of other clotting factors including factors V and VIII (marked decreases) and factors VII and IX (variable decreases) have also been reported. A low incidence of decrease in circulating platelets has been reported. Bleeding has been reported in a minority of patients with a demonstrable coagulopathy. Intracranial hemorrhage and fatal bleeding associated with low fibrinogen levels have been reported. Compensatory increased fibrinolytic activity has also been reported.

Transient bone marrow depression has rarely been observed as evidenced by a delay in return of hemoglobin or hematocrit levels to normal in patients undergoing hematologic remission of leukemia. Marked leukopenia has also been reported.

Hypertriglyceridemia has been reported.

Gastrointestinal

Gastrointestinal side effects have included nausea, vomiting, and anorexia. Acute hemorrhagic pancreatitis (sometimes fatal) has also been reported.

General

General side effects include chills, fever, abdominal cramps, weight loss, and headache. Fatal hyperthermia has also been reported.

Hepatic

Hepatic side effects have included elevations of SGOT, SGPT, alkaline phosphatase, bilirubin, and depression of serum albumin, cholesterol, and plasma fibrinogen. Both increases and decreases in total blood lipids have been reported. Marked hypoalbuminemia associated with peripheral edema has been reported. Fatty changes in the liver have been documented by biopsy. Malabsorption syndrome has also been reported.

Most hepatic abnormalities are usually reversible upon discontinuation of therapy and some reversal has been reported during the course of therapy.

Nervous system

Nervous system side effects have included somnolence, fatigue, seizures, coma, and confusion. A Parkinson-like syndrome with tremor and a progressive increase in muscle tone has been reported rarely.

Nervous system side effects have usually reversed spontaneously upon discontinuation of asparaginase.

Cardiovascular

Cardiovascular side effects have included one reported case of acute myocardial infarction.

Dermatologic

Dermatologic side effects have included skin rashes and urticaria.

Musculoskeletal

Musculoskeletal side effects have included arthralgia.

Respiratory

Respiratory side effects have included respiratory distress.

Metabolic

The syndrome resembles hyperosmolar nonketonic hyperglycemia. While the syndrome usually responds to discontinuation of asparaginase, judicious use of IV fluid, and insulin, it has occasionally been fatal.

Metabolic side effects have included a low incidence of hyperglycemia with glycosuria and polyuria.

Psychiatric

Psychiatric side effects have included depression, agitation, confusion, paranoia, and hallucinations.

Renal

Renal side effects include acute renal shut down and fatal renal insufficiency. Proteinuria has been reported infrequently.

Other

Other side effects have included interference with the interpretation of thyroid function tests by production of a rapid and marked reduction in serum concentrations of thyroxine-binding globulin within days after the first dose.

Serum concentrations of thyroxine-binding globulin have been reported to return to pretreatment values within four weeks of the last dose.

Oncologic

Oncologic side effects have included reports of small increases in pulmonary adenomas in animal studies..

Immunologic

Immunosuppressive activity has been reported in animal experiments.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

Hide
(web2)