Cenolate Side Effects

Generic Name: ascorbic acid,acerola

Please note - some side effects for Cenolate may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects of Cenolate - for the Consumer

Cenolate Injection

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Cenolate Injection:

Burning, pain, stinging, or swelling at the injection site.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bone pain; mental or mood changes; muscle weakness; severe or persistent diarrhea.

Side Effects by Body System

Renal

Renal side effects have included oxalate and urate kidney stones.

Hyperoxaluria appears to be dose-related.

Nervous system

Nervous system side effects have included dizziness, faintness, fatigue, and headache in less than 1% of patients. Migraine headache has also been reported.

Migraine headache has been reported with a daily dose of 6 grams.

The manufacturer reports temporary dizziness and faintness may be associated with too rapid of a rate during intravenous administration.

Other

Conditional scurvy is reported to occur following excessive doses of ascorbic acid over a prolonged period of time. The mechanism of action for this condition is thought to be that large doses of ascorbic acid condition the patient over time for rapid clearance of ascorbic acid resulting in scurvy. The plasma levels of ascorbic acid appear to remain within normal limits. The actual existence of conditional scurvy remains controversial.

Other side effects have included flank pain in less than 1% of patients. Conditional scurvy has also been reported.

Gastrointestinal

Nausea, diarrhea, and abdominal cramps appears to be associated with doses exceeding 2 g per day, although there have been some reports with as little as 1 g per day.

Esophagitis appears to be associated with prolonged or increased contact of ascorbic acid tablets with the esophageal mucosa.

Gastrointestinal side effects have included nausea, diarrhea, abdominal cramps, and esophagitis.

Hematologic

Hematologic side effects have included hemolysis.

The majority of hemolysis reports have been associated with patients who have concurrent glucose-6-phosphate dehydrogenase deficiency.

Local

Local side effects have included transient mild soreness at the site of injection.

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