Brevibloc Side Effects
Generic Name: esmolol
Note: This page contains information about the side effects of esmolol. Some of the dosage forms included on this document may not apply to the brand name Brevibloc.
Not all side effects for Brevibloc may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
For the Consumer
Applies to esmolol: intravenous solution
Along with its needed effects, esmolol (the active ingredient contained in Brevibloc) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking esmolol:More common
- Blurred vision
- dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
- increased sweating
- unusual tiredness or weakness
- Itching of skin
- numbness and tingling of face, fingers, or toes
- pain in arms, legs, or lower back, especially pain in calves and/or heels upon exertion
- pale, bluish-colored, or cold hands or feet
- weak or absent pulses in legs
- Blue lips and fingernails
- burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- changes in skin color
- changes in vision
- chest pain or discomfort
- coughing that sometimes produces a pink frothy sputum
- decrease in frequency of urination
- decrease in urine volume
- difficult, fast, noisy breathing, sometimes with wheezing
- difficulty in passing urine (dribbling)
- difficulty with speaking
- feeling of warmth
- feeling unusually cold
- lightheadedness, dizziness, or fainting
- loss of bladder control
- muscle spasm or jerking of all extremities
- no heartbeat
- pain, tenderness, or swelling of foot or leg
- painful urination
- paleness of skin
- peeling of skin
- redness of the face, neck, arms and occasionally, upper chest
- shortness of breath
- slow or irregular heartbeat
- small clicking, bubbling, or rattling sounds in the lung when listening with a stethoscope
- sudden loss of consciousness
- swelling, redness, or burning of skin where the needle is placed
- tightness in chest
Get emergency help immediately if any of the following symptoms of overdose occur while taking esmolol:Symptoms of overdose
- Dilated neck veins
- extreme fatigue
- irregular breathing
- no blood pressure or pulse
- stopping of heart
- swelling of face, fingers, feet, or lower legs
- weight gain
Some side effects of esmolol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- Hardening or thickening of skin where the needle is placed
- dry mouth
- sleepiness or unusual drowsiness
- trouble sleeping
- Acid or sour stomach
- change in taste or bad, unusual, or unpleasant (after) taste
- difficulty having a bowel movement (stool)
- feeling sad or empty
- lack of appetite
- lack or loss of strength
- loss of interest or pleasure
- shoulder pain
- stomach soreness, discomfort, upset, or pain
- stuffy nose
- trouble concentrating
- weight loss
For Healthcare Professionals
Applies to esmolol: intravenous solution
Effects and side effects of esmolol (the active ingredient contained in Brevibloc) are usually brief and transient because of the relatively short half-life of esmolol (approximately 9 minutes).
Significant reductions of left and right ventricular ejection fractions, increases in pulmonary capillary wedge pressure, and decreases in cardiac output have been reported in patients with a mean left ventricular (LV) ejection fraction of 0.27. None of these changes were clinically significant, but the investigators advise cautious monitoring of the hemodynamic status in patients with LV dysfunction, especially at dosages greater than 200 mcg per kg per min.
Cardiovascular side effects are the most common. Symptomatic (diaphoresis or dizziness) and asymptomatic hypotension occur in up to 14% and 50% of patients, respectively. Hypotension is more likely with dosages greater than 200 mcg per kg per min. Peripheral ischemia, pallor, flushing, chest pain, syncope, bradycardia, pulmonary edema, and heart block have been reported in less than 1% of patients. Hemodynamic changes are reported in patients with left ventricular dysfunction.
Nervous system side effects include dizziness, weakness, somnolence or headache in 3% to 7% of patients. Paresthesias, anorexia, asthenia, lightheadedness, agitation and general irritability occur in less than 1% of patients. One fatal seizure associated with esmolol (the active ingredient contained in Brevibloc) is reported.
Gastrointestinal complaints are mainly limited to nausea in 6% of patients. Dyspepsia, general abdominal discomfort, dry mouth, and vomiting are reported in less than 1% of patients.
Respiratory system side effects including bronchospasm, dyspnea, wheezing nasal congestion, rhonchi, and rales have been reported in less than 1% of patients. As with other beta-adrenergic receptor antagonists, esmolol (the active ingredient contained in Brevibloc) should be given cautiously, if at all, to patients with a reactive airways disease.
Local intravenous site reactions including inflammation and induration have been reported (approximately 8%). Edema, erythema, skin discoloration, burning, thrombophlebitis, and local skin necrosis have been reported in less than 1% of patients.
Psychiatric side effects including depression and abnormal thinking have been rarely reported (<1%).
Genitourinary effects including urinary retention have been rarely reported (<1%).
Other side effects including speech disorder, abnormal vision, midscapular pain, rigors, and fever have been reported rarely (<1%).
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