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Aldoril D30 Side Effects

Generic Name: hydrochlorothiazide / methyldopa

Note: This page contains information about the side effects of hydrochlorothiazide / methyldopa. Some of the dosage forms included on this document may not apply to the brand name Aldoril D30.

For the Consumer

Applies to hydrochlorothiazide / methyldopa: oral tablet

In addition to its needed effects, some unwanted effects may be caused by hydrochlorothiazide / methyldopa. In the event that any of these side effects do occur, they may require medical attention.

Severity: Major

You should check with your doctor immediately if any of these side effects occur when taking hydrochlorothiazide / methyldopa:

Rare:
  • Unexplained fever shortly after starting to take this medicine

Severity: Moderate

If any of the following side effects occur while taking hydrochlorothiazide / methyldopa, check with your doctor or nurse as soon as possible:

Signs and symptoms of too much potassium loss
  • Dry mouth
  • increased thirst
  • irregular heartbeats
  • muscle cramps or pain
  • nausea or vomiting
  • unusual tiredness or weakness
  • weak pulse
Less common:
  • Mental depression or anxiety
  • nightmares or unusually vivid dreams
Rare:
  • Cough or hoarseness
  • dark or amber urine
  • diarrhea or stomach cramps (severe or continuing)
  • fever, chills, troubled breathing, and fast heartbeat
  • general feeling of discomfort or illness or weakness
  • joint pain
  • lower back or side pain
  • painful or difficult urination
  • pale stools
  • skin rash, hives, or itching
  • stomach pain (severe) with nausea and vomiting
  • tiredness or weakness after having taken this medicine for several weeks (continuing)
  • yellow eyes or skin

Severity: Minor

Some of the side effects that can occur with hydrochlorothiazide / methyldopa may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Dizziness or light-headedness when getting up from a lying or sitting position
  • drowsiness
  • dryness of mouth
  • headache
Less common:
  • Decreased sexual ability or interest in sex
  • diarrhea
  • increased sensitivity of skin to sunlight (skin rash, itching, redness or other discoloration of skin or severe sunburn after exposure to sunlight)
  • loss of appetite
  • numbness, tingling, pain, or weakness in hands or feet
  • slow heartbeat
  • stuffy nose
  • swelling of breasts or unusual milk production

For Healthcare Professionals

Applies to hydrochlorothiazide / methyldopa: oral tablet

Cardiovascular

Hydrochlorothiazide:
Frequency not reported: Hypotension, orthostatic hypotension, necrotizing angiitis, vasculitis

Methyldopa:
Frequency not reported: Angina pectoris aggravated, congestive heart failure, prolonged carotid sinus hypersensitivity, orthostatic hypotension, bradycardia, myocarditis, pericarditis, vasculitis[Ref]

Dermatologic

Hydrochlorothiazide:
Frequency not reported: Cutaneous vasculitis, photosensitivity, urticaria, rash, purpura, erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis, toxic epidermal necrolysis, alopecia

Methyldopa:
Frequency not reported: Toxic epidermal necrolysis, rash[Ref]

Gastrointestinal

Hydrochlorothiazide:
Frequency not reported: Pancreatitis, diarrhea, vomiting, sialadenitis, cramping, constipation, gastric irritation, nausea

Methyldopa:
Frequency not reported: Pancreatitis, colitis, vomiting, diarrhea, sialadenitis, sore tongue, black tongue, nausea, constipation, distention, flatus, dry mouth[Ref]

Hematologic

Hydrochlorothiazide:
Frequency not reported: Aplastic anemia, agranulocytosis, leukopenia, hemolytic anemia, thrombocytopenia

Methyldopa:
Frequency not reported: Bone marrow depression, leukopenia, granulocytopenia, thrombocytopenia, hemolytic anemia, Coombs test positive, eosinophilia[Ref]

Nervous system

Hydrochlorothiazide:
Frequency not reported: Vertigo, paresthesias, dizziness, headache

Methyldopa:
Frequency not reported: Sedation, headache, Parkinsonism, Bell's palsy, mental acuity decreased, involuntary choreoathetotic movements, cerebrovascular insufficiency symptoms, dizziness, lightheadedness, paresthesias[Ref]

Hepatic

Hydrochlorothiazide:
Frequency not reported: Intrahepatic cholestatic jaundice

Methyldopa:
Frequency not reported: Liver disorders, hepatitis, jaundice, liver function tests abnormal[Ref]

Other

Hydrochlorothiazide:
Frequency not reported: Weakness, fever

Methyldopa:
Frequency not reported: Asthenia, weakness, edema, drug-related fever, breast enlargement, gynecomastia, lactation[Ref]

Psychiatric

Hydrochlorothiazide:
Frequency not reported: Restlessness

Methyldopa:
Frequency not reported: Psychic disturbances, nightmares, reversible mild psychoses, depression, libido decreased[Ref]

Genitourinary

Hydrochlorothiazide:
Frequency not reported: Glycosuria, impotence

Methyldopa:
Frequency not reported: Amenorrhea, impotence[Ref]

Immunologic

Hydrochlorothiazide:
Frequency not reported: Anaphylactic reactions

Methyldopa:
Frequency not reported: Antinuclear antibody test positive, LE cells, rheumatoid factor[Ref]

Metabolic

Hydrochlorothiazide:
Frequency not reported: Anorexia, electrolyte imbalance, hyperglycemia, hyperuricemia

Methyldopa:
Frequency not reported: Weight gain[Ref]

Musculoskeletal

Hydrochlorothiazide:
Frequency not reported: Muscle spasm

Methyldopa:
Frequency not reported: Lupus-like syndrome, arthralgia, myalgia[Ref]

Renal

Hydrochlorothiazide:
Frequency not reported: Renal failure, renal dysfunction, interstitial nephritis

Methyldopa:
Frequency not reported: BUN increased[Ref]

Respiratory

Hydrochlorothiazide:
Frequency not reported: Respiratory distress, pneumonitis, pulmonary edema

Methyldopa:
Frequency not reported: Nasal stuffiness[Ref]

Endocrine

Methyldopa:
Frequency not reported: Hyperprolactinemia[Ref]

Ocular

Hydrochlorothiazide:
Frequency not reported: Transient blurred vision, xanthopsia[Ref]

References

1. "Product Information. Aldoril (methyldopa-hydrochlorothiazide)." Merck & Co, Inc, West Point, PA.

Not all side effects for Aldoril D30 may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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