Akineton Side Effects

Please note - some side effects for Akineton may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Side Effects of Akineton - for the Consumer

Akineton

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Akineton:

Agitation; blurred vision; constipation; dizziness or lightheadedness when sitting up or standing; drowsiness; dry mouth, nose, or throat; nausea; nervousness; stomach upset.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); anxiety; behavior changes; chest pain; confusion; disorientation; exaggerated sense of well-being; fast, slow, or irregular heartbeat; flushing; hallucinations; loss of coordination; memory loss; mood or mental changes; seizures; trouble urinating.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

Akineton Side Effects - for the Professional

Akineton

Atropine-like side effects such as dry mouth; blurred vision; drowsiness; euphoria or disorientation; urinary retention; postural hypotension; constipation; agitation; disturbed behavior may been seen. A case of generalized choreic movements has been reported in a Parkinson's disease patient when biperiden was added to carbidopa/levodopa. A reduction in rapid eye movement (REM) sleep, characterized by increased REM latency and decreased percentage of REM sleep, has been reported. There usually are no significant changes in blood pressure or heart rate in patients who have been given the parenteral form of Akineton. Mild transient postural hypotension and bradycardia may occur. These side effects can be minimized or avoided by slow intravenous administration. No local tissue reactions have been reported following intramuscular injection. If gastric irritation occurs following oral administration, it can be avoided by administering the drug during or after meals.

The central anticholinergic syndrome can occur as an adverse reaction to properly prescribed anticholinergic medication. See OVERDOSAGE section for signs and symptoms of the central anticholinergic syndrome, and for treatment.

Side Effects by Body System - for Healthcare Professionals

Nervous system

A case of choreic movements was reported in a patient on concomitant therapy of biperiden and carbidopa/levodopa.

Nervous system side effects have included drowsiness, choreic movements, reduced rapid eye movement sleep, and anticholinergic syndrome. Symptoms of central anticholinergic syndrome include: dilated, sluggish pupils; warm, dry skin; flushing; decreased respiratory tract secretions; foul breath; increased body temperature; decrease bowel sounds; urinary retention; tachycardia/cardiac arrhythmias;delirium, disorientation, anxiety, hallucinations, confusion, incoherence; agitation; hyperactivity, ataxia, loss of memory; paranoia; combativeness and seizures. Central anticholinergic syndrome may progress to stupor, coma, paralysis, cardiac/respiratory arrest and death. Orthostatic dizziness, hypokinesia, and headache have also been reported.

Gastrointestinal

Gastrointestinal side effects have included dry mouth, constipation, gastric irritation, nausea, vomiting, and increased salivation.

Psychiatric

Psychiatric side effects have included euphoria, disorientation, agitation, disturbed behavior, and concentration difficulties.

Other

Other side effects have included asthenia.

Hypersensitivity

Hypersensitivity side effects have included allergic skin reactions.

Genitourinary

Genitourinary side effects have included urinary retention.

Ocular

Ocular side effects have included blurred vision.

Cardiovascular

Postural hypotension and bradycardia may be minimized or eliminated by slow intravenous administration.

Cardiovascular side effects have included postural hypotension and bradycardia when administered parenterally.

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