Vasopressin Pregnancy and Breastfeeding Warnings
Vasopressin Pregnancy Warnings
There have been several reports in which vasopressin or desmopressin (DDAVP) was used safely to treat diabetes insipidus during human pregnancy. There appears to be a decrease in the plasma concentration of vasopressin during the first and second trimesters, and a 3-fold increase in the plasma concentration of vasopressin in the last trimester and during labor. In vivo and in vitro data have shown that vasopressin and other structurally related polypeptides increase the frequency and amplitude of uterine contractions.
Vasopressin has been assigned to pregnancy category C by the FDA. Animal studies have not been reported. There are no controlled data in human pregnancy. Vasopressin is only recommended for use during pregnancy when benefit outweighs risk.
Vasopressin Breastfeeding Warnings
There are no data on the excretion of vasopressin into human milk. Patients receiving vasopressin or other structurally related polypeptides have been reported to breast-feed without apparent adverse effects on the nursing infant. The manufacturer recommends that caution be used when administering vasopressin to nursing women.
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