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Trastuzumab Pregnancy and Breastfeeding Warnings

Trastuzumab is also known as: Herceptin

Trastuzumab Pregnancy Warnings

Trastuzumab has been assigned to pregnancy category D by the FDA. Animal studies have revealed that in mutant mice lacking HER2, embryos died in early gestation. There are no controlled data in human pregnancy. Postmarketing case reports suggest that trastuzumab use during pregnancy increases the risk of oligohydramnios during the second and third trimesters. Trastuzumab is only recommended for use during pregnancy when there are no alternatives and benefit outweighs risk.

A case has been reported of a woman who received three cycles of trastuzumab during her first trimester and had no complications.

Trastuzumab Breastfeeding Warnings

There are no data on the excretion of trastuzumab into human milk. Because human IgG is excreted in human milk and because of the potential for serious adverse reactions due to trastuzumab in nursing infants, women are advised to discontinue nursing during trastuzumab therapy and for six months after the last dose of trastuzumab.

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