Questions about Atrial Fibrillation? Get answers from our expert.

Simvastatin / sitagliptin Pregnancy and Breastfeeding Warnings

Simvastatin / sitagliptin is also known as: Juvisync

Simvastatin / sitagliptin Pregnancy Warnings

Simvastatin-sitagliptin has been assigned to pregnancy category X by the FDA. While animal studies with simvastatin failed to reveal evidence of teratogenicity, animal studies with other HMG-CoA reductase inhibitors revealed an increase in the incidence of skeletal malformations. There are no controlled data in human pregnancy. However, HMG-CoA reductase inhibitors are known to inhibit biosynthetic processes necessary in fetal development. Lipid lowering drugs offer no benefit during pregnancy, because cholesterol and cholesterol derivatives are needed for normal fetal development. Atherosclerosis is a chronic process, and discontinuation of lipid-lowering drugs during pregnancy should have little impact on long-term outcomes of primary hypercholesterolemia therapy. Simvastatin-sitagliptin is considered contraindicated in women who are or may become pregnant.

Simvastatin / sitagliptin Breastfeeding Warnings

There are no data on the excretion of simvastatin or sitagliptin into human milk. A small amount of another drug in the same class as simvastatin is excreted in human milk. Simvastatin-sitagliptin is considered to be contraindicated by the manufacturer.

See Also...

Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Wolters Kluwer Health and Drugs.com is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2008 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.

Questions about Atrial Fibrillation? Get answers from our expert. Watch Video

Close
Hide
(web2)