Penicillamine Pregnancy and Breastfeeding Warnings
Penicillamine Pregnancy Warnings
Penicillamine has been assigned to pregnancy category D by the FDA. Penicillamine can cause fetal harm when administered to a pregnant woman. Penicillamine has been shown to be embryotoxic and teratogenic in rats. There are no controlled data in human pregnancy. Although normal outcomes have been reported, characteristic congenital cutis laxa and associated birth defects have been reported in infants born of mothers who received therapy with penicillamine during pregnancy. Several conflicting recommendations have appeared in the literature concerning the use of penicillamine during pregnancy. Although evidence is incomplete, maintaining the daily dose at 500 mg or less may reduce the incidence of penicillamine-induced toxicity in the newborn. The manufacturer recommends, however, that the daily dose be limited to 750 mg and, if cesarean section is planned, the dose should be limited to 250 mg/day for 6 weeks before delivery and postoperatively until wound healing is complete.
Penicillamine Breastfeeding Warnings
Penicillamine is excreted into human milk. Breast-feeding is considered contraindicated by the manufacturer.
A 2000 review stated that no adverse effects in nursing infants have been reported by nursing mothers who were taking penicillamine, even though one study found lower amounts of zinc and copper in milk.
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