Panitumumab Pregnancy and Breastfeeding Warnings

Panitumumab is also known as: Vectibix

Panitumumab Pregnancy Warnings

Panitumumab has been assigned to pregnancy category C by the FDA. Animal studies have revealed evidence of embryolethality and abortifacient effects. There are no controlled data in human pregnancy. Panitumumab should only be given during pregnancy when there are no alternatives and benefit outweighs risk. In women of childbearing potential, appropriate contraceptive measures must be used during treatment with panitumumab and for six months following the last dose of panitumumab.

Human IgG is known to cross the placental barrier. Therefore, panitumumab may be transmitted from the mother to the developing fetus. If panitumumab is used during pregnancy or the patient becomes pregnant while receiving the drug, she should be apprised of the potential risk for loss of the pregnancy or potential hazard to the fetus.

Panitumumab Breastfeeding Warnings

Published data suggest that breast milk antibodies do not enter the neonatal and infant circulation in substantial amounts.

There are no data on the excretion of panitumumab into human milk. Because human IgG is secreted into human milk, panitumumab might also be secreted. Women must be advised to discontinue nursing during treatment with panitumumab and for two months after the last dose of panitumumab.

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