Oxazepam Pregnancy and Breastfeeding Warnings

Oxazepam is also known as: Serax

Oxazepam Pregnancy Warnings

One study has reported information concerning the distribution of oxazepam in first trimester pregnancy. In that study women who had elected to undergo legal abortion received oxazepam four hours prior to the procedure. Sampling of placental tissue revealed oxazepam penetration of 31.5%. No oxazepam was detected in the amniotic fluid. Physicians are encouraged to register patients before fetal outcome is known (e.g., ultrasound, results of amniocentesis, etc) into the Antiepileptic Drug (AED) Pregnancy Registry at 1-888-233-2334 or 1-888-AED-AED4. This is an ongoing study at the Massachusetts General Hospital/Harvard Medical School. This study is designed to monitor the outcomes of pregnant women exposed to antiepileptic drugs in order to determine which therapies are associated with increased risk.

Oxazepam has not been formally assigned to a pregnancy category. An increased risk of congenital malformations has been associated with use of other benzodiazepines (such as chlordiazepoxide and diazepam) during the first trimester. Oxazepam has also been implicated in causing dysmorphic features, growth retardation and central nervous system defects in a small number of patients. There are no controlled data in human pregnancy. Oxazepam should only be given during pregnancy when there are no alternatives and benefit outweighs risk.

Oxazepam Breastfeeding Warnings

Oxazepam is excreted into human milk in small amounts. No cases of adverse effects in nursing infants have been reported although small amounts of oxazepam have been detected in one infant whose mother was taking both diazepam and oxazepam. Other benzodiazepines have been demonstrated to accumulate in human milk and have caused adverse effects, such as withdrawal, in nursing infants.

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