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Melphalan Pregnancy and Breastfeeding Warnings

Melphalan is also known as: Alkeran

Melphalan Pregnancy Warnings

Melphalan has been assigned to pregnancy category D by the FDA. Animal studies have revealed evidence of embryolethality and teratogenicity. There are no controlled data in human pregnancy. Melphalan has been reported to cause suppression of ovarian function in premenopausal women, resulting in amenorrhea in a significant number of patients. Both reversible and irreversible testicular suppression have also been reported. Melphalan should only be given during pregnancy when there are no alternatives and benefit outweighs risk. If this drug is used during pregnancy or if the patient becomes pregnant while receiving the drug, she should be made aware of the potential hazard to the fetus. Women of childbearing potential should be advised to avoid becoming pregnant.

Melphalan Breastfeeding Warnings

There are no data on the excretion of melphalan into human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions due to melphalan in nursing infants, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

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