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Measles virus vaccine / mumps virus vaccine / rubella virus vaccine Pregnancy and Breastfeeding Warnings

Measles virus vaccine / mumps virus vaccine / rubella virus vaccine is also known as: M-M-R II

Measles virus vaccine / mumps virus vaccine / rubella virus vaccine Pregnancy Warnings

Abnormalities suggestive of congenital rubella syndrome were not observed during a 10-year survey of 700 pregnant women who received rubella vaccine within 3 months before or after conception. Mumps virus infection during the first trimester may increase the rate of spontaneous abortion. Although mumps vaccine virus has been shown to infect the placenta and fetus, there is no evidence of congenital malformations in humans. Natural measles virus infection during pregnancy has been associated with an increased incidence of spontaneous abortion, stillbirth, congenital defects, and prematurity. There are no data on the use of measles virus vaccine during pregnancy; however, it is possible that the vaccine virus may also induce adverse fetal effects.

Measles/mumps/rubella vaccine has been assigned to pregnancy category C by the FDA. Animal studies have not been reported. There are no controlled data in human pregnancy. There is a theoretical risk of viral transmission to the fetus. The manufacturer's labeling states that measles/mumps/rubella vaccination is considered contraindicated during pregnancy and that pregnancy should be avoided for 3 months following vaccination. The Advisory Committee on Immunization Practices recommends that pregnancy be avoided for 4 weeks after vaccination, that women who become pregnant within that period be advised of the theoretical risk to the fetus, and that vaccination during pregnancy is generally not a reason to terminate the pregnancy.

Measles virus vaccine / mumps virus vaccine / rubella virus vaccine Breastfeeding Warnings

Rubella vaccine virus may be excreted in breast milk and transmitted to nursing infants. Severe disease has not been reported in exposed infants who were serologically positive for rubella infection; however, one infant had a mild illness characteristic of acquired rubella. There are no data on the excretion of measles or mumps vaccine virus into human milk. The manufacturer recommends that caution be used when administering measles/mumps/rubella vaccine to breast-feeding women. The U.S. Centers for Disease Control and Prevention (CDC) consider the administration of live virus vaccines compatible with breast-feeding.

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