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Isoniazid / pyrazinamide / rifampin Pregnancy and Breastfeeding Warnings

Isoniazid / pyrazinamide / rifampin is also known as: Rifater

Overview

If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking Isoniazid/Pyrazinamide/Rifampin while you are pregnant. Isoniazid/Pyrazinamide/Rifampin is found in breast milk. Do not breast-feed while taking Isoniazid/Pyrazinamide/Rifampin.

Isoniazid / pyrazinamide / rifampin Pregnancy Warnings

Isoniazid/pyrazinamide/rifampin has been assigned to pregnancy category C by the FDA. Animal studies have not been reported. Isoniazid animal studies have revealed evidence of embryolethality. Rifampin animal studies have revealed evidence of embryotoxicity and teratogenicity. There are no controlled data in human pregnancy. Isoniazid and rifampin have been reported to cross the placental barrier and rifampin has appeared in cord blood. Isolated cases of fetal malformations have been reported with rifampin. Postnatal hemorrhages in the mother and infant have been associated with the use of rifampin during the last few weeks of pregnancy, and administration of vitamin K may be indicated. Isoniazid/pyrazinamide/rifampin is only recommended for use during pregnancy when benefit outweighs risk.

Isoniazid / pyrazinamide / rifampin Breastfeeding Warnings

Isoniazid, pyrazinamide, and rifampin are excreted into human milk. The effects in the nursing infant are unknown. The manufacturer recommends that due to the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

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