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Immune globulin intravenous Pregnancy and Breastfeeding Warnings

Immune globulin intravenous is also known as: Bivigam, Carimune, Carimune NF, Flebogamma, Gamimune, Gamimune N 10%, Gamimune N 5%, Gammagard S/D, Gammaplex, Gammar IV, Gammar-P I.V., Gamunex, Iveegam En, Octagam, Panglobulin, Panglobulin NF, Polygam S/D, Privigen, Sandoglobulin, Venoglobulin-S 10%, Venoglobulin-S 5%

Immune globulin intravenous Pregnancy Warnings

Immune globulin intravenous human (IGIV) has been assigned to pregnancy category C by the FDA. Animal studies have not been reported. IGIV has been used successfully during human pregnancy. IGIV is only recommended for use during pregnancy when benefit outweighs risk.

IgG and IgG subclasses have been shown to cross the placenta after 32 weeks of gestation. Placental transfer also appears to be dose and possibly duration dependent. Sacher and colleagues reviewed the clinical indications for IGIV in pregnancy (e.g., hypogammaglobulinemia, immune thrombocytopenic purpura, alloimmune disorders) and recent reports have described the use of IGIV for the prevention of recurrent abortions due to antiphospholipid antibodies, prevention of intracranial hemorrhage in fetal alloimmune thrombocytopenia, neonatal congenital heart block due to maternal antibodies, and severe isoimmunization. No adverse effects have been noted in any of these reports.

See references

Immune globulin intravenous Breastfeeding Warnings

There are no data on the excretion of immune globulin intravenous (human) into human milk.

See references

References for pregnancy information

  1. "Product Information. Immune Globulin IV (Human). Sandoglobulin (immune globulin intravenous)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
  2. Sidiropoulos D, Herrmann U Jr, Morell A, von Muralt G, Barandun S "Transplacental passage of intravenous immunoglobulin in the last trimester of pregnency." J Pediatr 109 (1986): 505-8
  3. Valensise H, Vaquero E, de Carolis C, et al. "Normal fetal growth in women with antiphospholipid syndrome treated with high-dose intravenous immunoglobulin (IVIG)." Prenat Diagn 15 (1995): 509-17
  4. Gounder MP, Baker D, Saletan S, Monheit AG, Hultin MB, Coller BS "Intravenous gammaglobulin therapy in the management of a patient with idiopathic thrombocytopenic purpura and a warm autoimmune erythrocyte panagglutinin during pregnancy." Obstet Gynecol 67 (1986): 741-5
  5. Sacher RA, King JC "Intravenous gamma-globulin in pregnancy: a review." Obstet Gynecol Surv 44 (1988): 25-34
  6. Bussel JB, Berkowitz RL, McFarland JG, Lynch L, Chitkara U "Antenatal treatment of neonatal alloimmune thrombocytopenia." N Engl J Med 319 (1988): 1374-8
  7. Kaaja R, Julkunen H, Ammala P, Palosuo T, Kurki P "Intravenous immunoglobulin treatment of pregnant patients with recurrent pregnancy losses associated with antiphospholipid antibodies." Acta Obstet Gynecol Scand 72 (1993): 63-6
  8. Spinnato JA, Clark AL, Pierangeli SS, Harris EN "Intravenous immunoglobulin therapy for the antiphospholipid syndrome in pregnancy." Am J Obstet Gynecol 172 (1995): 690-4
  9. Briggs GG, Freeman RK, Yaffe SJ.. "Drugs in Pregnancy and Lactation. 5th ed." Baltimore, MD: Williams & Wilkins (1998):
  10. Clark AL, Gall SA "Clinical uses of intravenous immunoglobulin in pregnancy." Am J Obstet Gynecol 176 (1997): 241-53

References for breastfeeding information

  1. Briggs GG, Freeman RK, Yaffe SJ.. "Drugs in Pregnancy and Lactation. 5th ed." Baltimore, MD: Williams & Wilkins (1998):
  2. "Product Information. Immune Globulin IV (Human). Sandoglobulin (immune globulin intravenous)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.

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