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Ifosfamide Pregnancy and Breastfeeding Warnings

Ifosfamide is also known as: Ifex

Overview

Ifosfamide Solution has been shown to cause harm to the fetus. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Ifosfamide Solution while you are pregnant. Ifosfamide Solution is found in breast milk. Do not breast-feed while using Ifosfamide Solution.

Ifosfamide Pregnancy Warnings

Ifosfamide has been assigned to pregnancy category D by the FDA. Animal studies have revealed evidence of embryotoxicity, fetotoxicity, and teratogenicity at doses 5.0% to 7.5% of the human dose on a per m2 basis. This drug can cause gene mutations and chromosomal damage in vivo. Human data have revealed evidence of fetotoxicity. If ifosfamide is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus. In general, the use of ifosfamide during pregnancy is considered contraindicated.

Ifosfamide Breastfeeding Warnings

Ifosfamide is excreted into human milk. Because of the potential for serious adverse events and the tumorigenicity shown for ifosfamide in animal studies, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the nursing mother.

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