Ezetimibe/simvastatin Pregnancy and Breast Feeding Warnings
Ezetimibe/simvastatin is also known as: Vytorin
Overview
Do not use Ezetimibe/Simvastatin if you are pregnant. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. It is not known if Ezetimibe/Simvastatin is found in breast milk. Do not breast-feed while taking Ezetimibe/Simvastatin .
Ezetimibe/simvastatin Pregnancy Warnings
Ezetimibe-simvastatin has been assigned to pregnancy category X by the FDA. Animal studies with ezetimibe have revealed evidence of increased incidences of common fetal skeletal findings. Ezetimibe crossed the placenta in animal studies. While animal studies with simvastatin failed to reveal evidence of teratogenicity, animal studies with other HMG-CoA reductase inhibitors revealed an increase in the incidence of skeletal malformations. There are no controlled data in human pregnancy. However, HMG-CoA reductase inhibitors are known to inhibit biosynthetic processes necessary in fetal development. Ezetimibe-simvastatin use is considered contraindicated during pregnancy.
Ezetimibe/simvastatin Lactation Warnings
There are no data on the excretion of ezetimibe-simvastatin into human milk. However, the manufacturer considers ezetimibe-simvastatin to be contraindicated during breast-feeding.
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