Etidronate Pregnancy and Breastfeeding Warnings
Etidronate is also known as: Didronel, Didronel IV
Etidronate Pregnancy Warnings
Bisphosphonates are incorporated into the bone matrix, from where they are gradually released over periods of weeks to years. Therefore, there is a theoretical risk of fetal harm if a woman becomes pregnant after completing a course of bisphosphonate therapy. Animal studies using oral doses up to 100 mg/kg failed to reveal evidence of teratogenicity. However, at doses of 300 mg/day, skeletal malformations were noted in the offspring of rats. Skeletal effects are thought to be due to the pharmacological effect of the dug on bone. Doses 25 to 200 times the recommended human dose resulted in maternal toxicity and decrease in number of live births. There are no controlled animal pregnancy data with IV etidronate.
Etidronate has been assigned to pregnancy category C by the FDA. Etidronate has been shown to cause skeletal abnormalities in rats when given at oral dose levels of 300 mg/kg (15 to 60 times the human dose). Other effects on the offspring (including decreased live births) are at dosages that cause significant toxicity in the parent generation and are 25 to 200 times the human dose. There are no controlled data in human pregnancy. Etidronate is only recommended for use during pregnancy when there are no alternatives and benefit outweighs risk.
Etidronate Breastfeeding Warnings
There are no data on the excretion of etidronate into human milk. The manufacturer recommends that caution be used when administering etidronate to nursing women.
- Etidronate use while Breastfeeding (in more detail)
- etidronate Consumer Information
- Pregnancy Support Group
- FDA Pregnancy Categories
- Medicine use during Pregnancy
- Medicine use while Breastfeeding
- Safe Medications during Breastfeeding
Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Wolters Kluwer Health and Drugs.com is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This drug information does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2008 Multum Information Services, Inc. The information in contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.