Ethinyl estradiol Pregnancy and Breastfeeding Warnings
Ethinyl estradiol is also known as: Estinyl
Ethinyl estradiol Pregnancy Warnings
Estrogenic agents have been associated with urogenital abnormalities in offspring that manifest later in life. Vaginal adenosis, squamous cell dysplasia of the uterine cervix and vaginal cancer have developed later in life in female offspring. In the male offspring, the risks of urogenital abnormalities and testicular cancer later in life are increased.
Ethinyl estradiol has been assigned to pregnancy category X by the FDA. There are no controlled data in human pregnancy. Ethinyl estradiol is contraindicated during pregnancy.
Ethinyl estradiol Breastfeeding Warnings
Limited data are available on the excretion of ethinyl estradiol into human milk. The American Academy of Pediatrics considers ethinyl estradiol to be usually compatible with breast-feeding despite reports of "withdrawal" and "vaginal bleeding". Ethinyl estradiol has been shown to decrease to quantity and quality of the milk. Estrogens are not indicated for the prevention of postpartum breast engorgement. The manufacturer recommends that caution be used when administering estradiol to nursing women.
References for pregnancy information
- Heinonen O, Slone D, Shapiro S; Kaufman DW ed. "Birth Defects and Drugs in Pregnancy." Littleton, MA: Publishing Sciences Group, Inc. (1977): 297
References for breastfeeding information
- Committee on Drugs, 1992 to 1993 "The transfer of drugs and other chemicals into human milk." Pediatrics 93 (1994): 137-50
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