Eszopiclone Pregnancy and Breastfeeding Warnings

Eszopiclone is also known as: Lunesta

Eszopiclone Pregnancy Warnings

Animal studies have reported decreased fertility thought to be due to effects in both males and females. No females became pregnant when both males and females where treated with the highest doses. Other effects have been reported to include preimplantation loss, abnormal estrus cycles, decreases in sperm number and motility, and increases in morphologically abnormal sperm.

Eszopiclone has been assigned to pregnancy category C by the FDA. Animal studies have revealed evidence of slight reductions in fetal weight and evidence of developmental delay at maternally toxic doses. Increased postimplantation loss, decreased postnatal pup weights and survival, and increased pup startle response were reported to occur at all doses. Eszopiclone has no established use in labor and delivery. There are no controlled data in human pregnancy. Eszopiclone should only be given during pregnancy when benefits outweigh risks.

Eszopiclone Breastfeeding Warnings

There are no data on the excretion of eszopiclone into human milk. Because many drugs are excreted into human milk caution is recommended if eszopiclone is administered to a nursing woman.

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