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Doxepin topical Pregnancy and Breastfeeding Warnings

Doxepin topical is also known as: Prudoxin, Zonalon

Doxepin topical Pregnancy Warnings

Doxepin topical cream has been assigned to pregnancy category B by the FDA. Studies of doxepin given orally at high doses to rats and rabbits have not revealed evidence of teratogenicity. There are no controlled data in human pregnancy. Doxepin is only recommended for use during pregnancy when the benefit outweighs risk.

See references

Doxepin topical Breastfeeding Warnings

Doxepin is excreted into human milk in small amounts following oral administration. Respiratory depression has been reported in one breast-fed infant whose mother received oral doxepin. Detailed information concerning the effects of doxepin cream in lactation is not available. The American Academy of Pediatrics classified oral doxepin as a drug "whose effect on nursing infants is unknown but may be of concern".

See references

References for pregnancy information

  1. "Product Information. Zonalon (doxepin topical)." Medicis Dermatologics Inc, Phoneix, AZ.

References for breastfeeding information

  1. "Product Information. Zonalon (doxepin topical)." Medicis Dermatologics Inc, Phoneix, AZ.
  2. Matheson I, Pande H, Alertsen AR "Respiratory depression caused by N-desmethyldoxepin in breast milk ." Lancet 2 (1985): 1124
  3. Kemp J, Ilett KF, Booth J, Hackett LP "Excretion of doxepin and N-desmethyldoxepin in human milk." Br J Clin Pharmacol 20 (1985): 497-9
  4. Committee on Drugs, 1992 to 1993 "The transfer of drugs and other chemicals into human milk." Pediatrics 93 (1994): 137-50
  5. Llewellyn A, Stowe ZN "Psychotropic medications in lactation." J Clin Psychiatry 59 Suppl 2 (1998): 41-52

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