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Desipramine Pregnancy and Breastfeeding Warnings

Desipramine is also known as: Norpramin

Desipramine Pregnancy Warnings

Desipramine has not been formally assigned to a pregnancy category by the FDA. Use of desipramine during pregnancy has been associated with neonatal withdrawal. There are no controlled data in human pregnancy. Desipramine should only be given during pregnancy when there are no alternatives and benefit outweighs risk.

Desipramine Breastfeeding Warnings

Desipramine is excreted into human milk in small amounts. The American Academy of Pediatrics classifies desipramine as a drug "whose effect on nursing infants is unknown but may be of concern".

One case has been reported in which the level of desipramine and its metabolite , 2-hydroxydesipramine, were measured in the milk and the plasma of an infant and his mother. Concentrations were similar between the maternal plasma and breast milk; however, neither compound was detected in the infant's serum. The authors calculated that the 4 kg infant would ingest about 1/100th of the maternal dose of 300 mg/day in a 24 hour period.

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