Butorphanol Pregnancy and Breastfeeding Warnings
Butorphanol is also known as: Stadol
Butorphanol Pregnancy Warnings
There have been rare reports of infant respiratory distress/apnea associated with the administration of a dose of butorphanol within 2 hours of delivery, use of multiple drugs, use with additional analgesic or sedative drugs, or use in preterm pregnancies. The manufacturer has reported that a study (n=119) of the administration of 1 mg of IV butorphanol injection during labor was associated with transient (10 to 90 minute) sinusoidal fetal heart rate patterns, but was not associated with adverse neonatal outcomes. In the presence of abnormal fetal heart rates, butorphanol injection should be used with caution. Because butorphanol nasal spray has not been studied for use in labor, use of the nasal spray for labor is not recommended.
Butorphanol has been assigned to pregnancy category C by the FDA. Animal studies have reported a higher frequency of stillbirths and a higher incidence of post implantation loss than controls. There are no controlled data in human pregnancy before 37 weeks gestation. Butorphanol should be used during pregnancy only if the potential benefit justifies the potential risk to the infant.
Butorphanol Breastfeeding Warnings
Butorphanol has been detected in human milk. Adverse effects in the nursing infant are unlikely. The amount of butorphanol an infant may receive has been estimated to be 4 ug/L of milk in a mother receiving 2 mg IM 4 times a day. Butorphanol is considered to be compatible with breast-feeding by the American Academy of Pediatrics.
Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Wolters Kluwer Health and Drugs.com is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2008 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.