Butorphanol Pregnancy and Breastfeeding Warnings
Butorphanol is also known as: Stadol
Butorphanol Pregnancy Warnings
There have been rare reports of infant respiratory distress/apnea associated with the administration of a dose of butorphanol within 2 hours of delivery, use of multiple drugs, use with additional analgesic or sedative drugs, or use in preterm pregnancies. The manufacturer has reported that a study (n=119) of the administration of 1 mg of IV butorphanol injection during labor was associated with transient (10 to 90 minute) sinusoidal fetal heart rate patterns, but was not associated with adverse neonatal outcomes. In the presence of abnormal fetal heart rates, butorphanol injection should be used with caution. Because butorphanol nasal spray has not been studied for use in labor, use of the nasal spray for labor is not recommended.
Butorphanol has been assigned to pregnancy category C by the FDA. Animal studies have reported a higher frequency of stillbirths and a higher incidence of post implantation loss than controls. There are no controlled data in human pregnancy before 37 weeks gestation. Butorphanol should be used during pregnancy only if the potential benefit justifies the potential risk to the infant.
Butorphanol Breastfeeding Warnings
Butorphanol has been detected in human milk. Adverse effects in the nursing infant are unlikely. The amount of butorphanol an infant may receive has been estimated to be 4 ug/L of milk in a mother receiving 2 mg IM 4 times a day. Butorphanol is considered to be compatible with breast-feeding by the American Academy of Pediatrics.
- Butorphanol use while Breastfeeding (in more detail)
- butorphanol solution Consumer Information
- Pregnancy Support Group
- FDA Pregnancy Categories
- Medicine use during Pregnancy
- Medicine use while Breastfeeding
- Safe Medications during Breastfeeding
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