Atazanavir Pregnancy and Breast Feeding Warnings

Atazanavir is also known as: Reyataz

Overview

If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Atazanavir while you are pregnant. It is not known if Atazanavir is found in breast milk. Mothers infected with HIV should not breast-feed. There is a risk of passing the HIV infection or Atazanavir to the baby.

Atazanavir Pregnancy Warnings

Atazanavir has been assigned to pregnancy category B by the FDA. At maternal doses producing the systemic drug exposure levels equal to (in rabbits) or two times (in rats) those at the human clinical dose (400 mg once daily), atazanavir did not produce teratogenic results. There are no controlled data in human pregnancy. Hyperbilirubinemia has been reported frequently during atazanavir therapy and it is not known whether maternal use would lead to neonatal kernicterus. Hyperlactatemia and lactic acidosis syndrome (in some cases fatal) have been reported in patients, including pregnant women, taking atazanavir in combination with nucleoside analogs. Additional monitoring and therapeutic alternatives should be considered during the prepartum period. Atazanavir should be used during pregnancy only if the potential benefit outweighs the risk to the fetus. To monitor fetal outcomes of pregnant women exposed to atazanavir, an antiretroviral Pregnancy Registry as been established. Healthcare providers are encouraged to register patients by calling 1-800-258-4263.

Atazanavir Lactation Warnings

There are no data on the excretion of atazanavir into human milk. HIV-infected mothers should not breast-feed their infants due to the risk of transmission of HIV via breast milk.

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