Albuterol / ipratropium Pregnancy and Breastfeeding Warnings

Albuterol / ipratropium is also known as: Combivent, Combivent Respimat, DuoNeb

Albuterol / ipratropium Pregnancy Warnings

Albuterol-ipratropium has been assigned to pregnancy category C by the FDA. Animal studies with albuterol have demonstrated a teratogenic effect. No evidence of abnormalities have been reported in women receiving albuterol during pregnancy. Albuterol has been given systemically to inhibit preterm labor. Use of albuterol in pregnant women for relief of bronchospasm may interfere with uterine contractility. Pulmonary edema has been associated with intravenous use of albuterol in pregnant women. Metered dose inhalers employ lower doses and result in lower plasma concentrations following administration, thereby producing fewer adverse effects for the mother and fetus. Ipratropium has failed to reveal evidence of teratogenicity in animal studies. There are no controlled data in human pregnancy. Albuterol-ipratropium is only recommended for use during pregnancy when there are no alternatives and benefit outweighs risk.

One malformation, a renal obstruction, occurred with ipratropium use between 1982 and 1994 among 37 women who took this drug during the first trimester according to data taken from a study of Medicaid patients. One study of 12 pregnant asthmatics between 33 and 39 weeks gestation showed no significant effect of inhaled albuterol on maternal or fetal circulations. For the two hours immediately following a dose of two deep inhalations of 0.5% solution, no significant effect was seen on maternal blood pressure or heart rate, umbilical artery systolic/diastolic ratio, fetal aortic velocities or heart rate.

Albuterol / ipratropium Breastfeeding Warnings

There are no data on the excretion of albuterol or ipratropium into human milk. The manufacturer recommends that due to the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

See Also...

Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Wolters Kluwer Health and Drugs.com is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2008 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.

Hide
(web1)