Zinc Chloride

Pronunciation: zink
Class: Minerals

Trade Names

Zinc Chloride
- Injection, solution, concentrate 1 mg/mL

Pharmacology

Zinc is an important activator of many enzyme systems (eg, alkaline phosphatase, carbonic anhydrase, lactic dehydrogenase) and deficits are accompanied by a variety of functional disturbances.

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Pharmacokinetics

Elimination

Excreted primarily in the stool (approximately 90%) and, to a lesser extent, in the urine and perspiration.

Special Populations

Renal Function Impairment

No data available.

Hepatic Function Impairment

No data available.

Indications and Usage

For use as a supplement to IV solutions given for TPN.

Contraindications

Direct IM or IV injection.

Dosage and Administration

Zinc Supplement
Adults

IV 2.5 to 4 mg/day (2.5 to 4 mL/day) added to TPN. Additional 2 mg/day (2 mL/day) is suggested for acute catabolic states. For stable adults with fluid loss from the small bowel, an additional 12.2 mg/L of small bowel fluid loss (12.2 mL/L of small bowel fluid lost) or additional 17.1 mg/kg of stool or ileostomy output (17.1 mL/kg of stool or ileostomy output) is recommended.

Children Full-term infants and children up to 5 y of age

IV 100 mcg/kg/day (0.1 mL/kg/day) added to TPN.

Premature infants (birth weight less than 1,500 g) up to 3 kg in body weight

IV 300 mcg/kg/day (0.3 mL/kg/day) added to TPN.

General Advice

  • For IV use only after dilution. Not for direct IM or IV injection.
  • Dilute prior to administration in a volume of fluid not less than 100 mL.
  • Discard unused portion immediately after admixture procedure is completed.
  • Do not administer if particulate matter, cloudiness, or discoloration noted.

Storage/Stability

Store at 68° to 77°F.

Drug Interactions

None well documented.

Adverse Reactions

None well documented.

Precautions

Monitor

Frequently monitor zinc blood levels in patients who are receiving more than the usual maintenance dose level of zinc. Periodic determinations of serum copper and zinc are suggested.


Pregnancy

Category C (in doses above the RDA).

Lactation

Undetermined.

Elderly

Dose selection should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant drug therapy.

Renal Function

Use with caution; renal impairment may lead to zinc intoxication.

Administration

Direct IM or IV administration is contraindicated because the acidic pH of the solution may cause considerable tissue irritation. Administration of zinc in the absence of copper may cause a decrease in serum copper levels.

Aluminum toxicity

This product contains aluminum. Aluminum may reach toxic levels with prolonged parenteral administration if kidney function is impaired. Premature neonates are particularly at risk.

Overdosage

Symptoms

Blurred vision, decreased level of consciousness, diarrhea, hyperamylasemia, hypotension, hypothermia, jaundice, oliguria, profuse sweating, pulmonary edema, tachycardia, vomiting, and/or death.

Patient Information

  • Advise patient that medication will be prepared and administered by a health care provider in a health care setting.

Copyright © 2009 Wolters Kluwer Health.

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