Pantothenic Acid

(

Vitamin B 5

) Pronunciation: pan-to-THE-nik AS-id
Class: Water-soluble vitamin

Trade Names

Pantothenic acid
- Tablets, oral 100 mg
- Tablets, oral 200 mg
- Tablets, oral 500 mg

Pharmacology

Pantothenic acid is a precursor of coenzyme A, which is a cofactor for a variety of enzyme-catalyzed reactions involving transfer of acetyl groups. Functions of pantothenic acid include oxidative metabolism of carbohydrates, gluconeogenesis, synthesis and degradation of fatty acids, and synthesis of steroids (cholesterol), steroid hormones, sphingosine, citrate, acetoacetate, and porphyrins.

Pharmacokinetics

Absorption

Absorbed from the GI tract.

Distribution

Distributed to all tissues in concentrations ranging from 2 to 45 mcg/g.

Elimination

Approximately 70% excreted from the urine.

Special Populations

Renal Function Impairment

No data available.

Hepatic Function Impairment

No data available.

Indications and Usage

As a dietary supplement to treat pantothenic acid deficiency.

Contraindications

Hypersensitivity to pantothenic acid.

Dosage and Administration

Dietary Reference Intakes
Lactation

PO 7 mg/day (Adequate Intake (AI) value).

Pregnancy

PO 6 mg/day (AI value).

Adults and Children 14 y of age and older

PO 5 mg/day (AI value).

Children 9 to 13 y of age

PO 4 mg/day (AI value).

Children 4 to 8 y of age

PO 3 mg/day (AI value).

Children 1 to 3 y of age

PO 2 mg/day (AI value).

Children 7 to 12 mo

1.8 mg/day (AI value).

Children 0 to 6 mo

1.7 mg/day (AI value).

Pantothenic Acid Deficiency
Adults

PO 1 or 2 tablets daily.

General Advice

  • Should be taken with a meal.

Storage/Stability

Store between 59° and 86°F in a cool, dry place away from direct heat, light, and moisture.

Drug Interactions

Biotin

Life-threatening eosinophilic pleuropericarditis has been reported with concurrent use.

Adverse Reactions

Dermatologic

Rash.

GI

Diarrhea at large doses.

Precautions

Pregnancy

Category A .

Lactation

Excreted in human breast milk. Considered compatible with breast-feeding per Briggs' Drugs in Pregnancy and Lactation .

Overdosage

Symptoms

Overdosage has not been reported.

Patient Information

  • Advise patients to take with food.
  • Advise patients not to take large doses of vitamins (megadoses or megavitamin therapy) while taking this medication unless otherwise directed by their health care provider.
  • Advise patients to report any of the following severe adverse reactions to their health care provider immediately: severe allergic reactions (eg, rash; hives; difficultly breathing; tightness in the chest; swelling of the mouth face, lips, or tongue).

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