Vitamin B 5) Pronunciation: pan-to-THE-nik AS-id
Class: Water-soluble vitamin
- Tablets, oral 100 mg
- Tablets, oral 200 mg
- Tablets, oral 500 mg
Pantothenic acid is a precursor of coenzyme A, which is a cofactor for a variety of enzyme-catalyzed reactions involving transfer of acetyl groups. Functions of pantothenic acid include oxidative metabolism of carbohydrates, gluconeogenesis, synthesis and degradation of fatty acids, and synthesis of steroids (cholesterol), steroid hormones, sphingosine, citrate, acetoacetate, and porphyrins.
Absorbed from the GI tract.
Distributed to all tissues in concentrations ranging from 2 to 45 mcg/g.
Approximately 70% excreted from the urine.
Special PopulationsRenal Function Impairment
No data available.Hepatic Function Impairment
No data available.
Indications and Usage
As a dietary supplement to treat pantothenic acid deficiency.
Hypersensitivity to pantothenic acid.
Dosage and AdministrationDietary Reference Intakes
PO 7 mg/day (Adequate Intake (AI) value).Pregnancy
PO 6 mg/day (AI value).Adults and Children 14 y of age and older
PO 5 mg/day (AI value).Children 9 to 13 y of age
PO 4 mg/day (AI value).Children 4 to 8 y of age
PO 3 mg/day (AI value).Children 1 to 3 y of age
PO 2 mg/day (AI value).Children 7 to 12 mo
1.8 mg/day (AI value).Children 0 to 6 mo
1.7 mg/day (AI value).Pantothenic Acid Deficiency
PO 1 or 2 tablets daily.
- Should be taken with a meal.
Store between 59° and 86°F in a cool, dry place away from direct heat, light, and moisture.
Life-threatening eosinophilic pleuropericarditis has been reported with concurrent use.
Diarrhea at large doses.
Category A .
Excreted in human breast milk. Considered compatible with breast-feeding per Briggs' Drugs in Pregnancy and Lactation .
Overdosage has not been reported.
- Advise patients to take with food.
- Advise patients not to take large doses of vitamins (megadoses or megavitamin therapy) while taking this medication unless otherwise directed by their health care provider.
- Advise patients to report any of the following severe adverse reactions to their health care provider immediately: severe allergic reactions (eg, rash; hives; difficultly breathing; tightness in the chest; swelling of the mouth face, lips, or tongue).
Copyright © 2009 Wolters Kluwer Health.