Pronunciation: mag-NEE-zee-uhm SIH-trate
Class: Mineral, Laxative
Citrate of Magnesia
- Solution 1.745 g per 30 mL
Attracts and retains water in intestinal lumen, thereby increasing intraluminal pressure and inducing urge to defecate.
Up to 20% magnesium citrate is absorbed.
Magnesium citrate is excreted by renal elimination.
Onset is 0.5 to 5 h.
Indications and Usage
Short-term treatment of constipation; evacuation of colon for rectal and bowel evaluations.
Hypersensitivity to any ingredient; nausea, vomiting or other symptoms of appendicitis; acute surgical abdomen; fecal impaction; intestinal obstruction; undiagnosed abdominal pain; intestinal bleeding; renal disease.
Dosage and AdministrationAdults
PO 1 glassful (approximately 240 mL) prn.Children (6 to 12 yr of age)
PO 50 to 100 mL. Repeat if necessary.Children (2 to 6 yr of age)
PO 4 to 12 mL.
Store in tightly closed container in cool dry place.
Reduced anti-infective action.Penicillamine
Reduced action of penicillamine.Tetracyclines
Impaired absorption of tetracyclines.
Laboratory Test Interactions
None well documented.
Excessive bowel activity (eg, cramping, diarrhea, nausea, vomiting); perianal irritation; bloating; flatulence; abdominal cramping.
Sweating; weakness; fluid and electrolyte imbalance.
Pregnancy category undetermined.
Exercise caution; consult health care provider. One 6-wk old infant developed magnesium poisoning after several doses for constipation.
Avoid in patients with renal dysfunction. Hypermagnesemia and toxicity may occur due to decreased clearance of magnesium ion.
Chronic use of laxatives may lead to laxative dependency, which may result in fluid and electrolyte imbalances, steatorrhea, osteomalacia and vitamin and mineral deficiencies.
Fluid and electrolyte imbalance
Excessive laxative use may lead to significant fluid and electrolyte imbalance.
Rectal bleeding or failure to respond
May indicate serious condition requiring further attention.
Severe/protracted diarrhea, fluid and electrolyte disturbances, hypermagnesemia.
- Explain that drug should not be used routinely for constipation; dependence can result.
- Instruct patient to report any of the following symptoms to health care provider: unrelieved constipation, vomiting, diarrhea, abdominal fullness, rectal bleeding, dizziness and muscle cramps.
- Review information on proper use and storage of medication.
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