Hepatitis B Immune Globulin (HBIG)

Trade Names:
BayHep B
- Injection 217 units/mL

Trade Names:
Nabi-HB
- Injection 312 units/mL

Pharmacology

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Directly neutralizes hepatitis B virus.

Indications and Usage

For passive, transient prevention of hepatitis B infection after viral exposure via needlestick or mucous membrane contact; prevention of hepatitis B in infants born to HBsAg-positive mothers. Most effective when used within 7 days of exposure.

Contraindications

None well documented.

Dosage and Administration

IM 0.06 mL/kg (usually 3 to 5 mL). Administer as soon as possible after exposure and repeat 28 to 30 days later.

IM 0.5 mL. Administer first HBIG dose as soon as possible, preferably less than 12 h after birth. Also give hepatitis B vaccine. If hepatitis B vaccine is declined, repeat HBIG at 3 and 6 mo.

General Advice

• Inspect solution for particulate matter and discoloration before administration.
• Administer IM, preferably in anterolateral aspects of upper thigh or deltoid muscle in adults and children. In newborns, administer IM in anterolateral thigh. Do not give IV.
• If gluteal region used, use only upper outer quadrant. Avoid central region to reduce risk of injury to sciatic nerve.

Storage/Stability

Store vials in refrigerator (36° to 46°F). Do not freeze. Administer within 6 h after vial has been entered.

Drug Interactions

Give HBIG with caution to people receiving anticoagulant therapy.

To avoid inactivating vaccines containing live viruses (except measles vaccine) or bacteria, give live vaccines 3 mo after HBIG.

Laboratory Test Interactions

None well documented.

Adverse Reactions

Miscellaneous

Local pain and tenderness at injection site; urticaria; angioedema; anaphylactic reactions.

Precautions

Pregnancy

Category C .

Lactation

Undetermined.

Overdosage

Symptoms

Pain, tenderness.

Patient Information

• Instruct parent to vaccinate all at-risk infants as soon after birth as possible and again at 3 mo.
• Instruct patient that therapy is useful as postexposure prophylaxis as soon after exposure as possible (preferably within 7 days.)
• Provide patient or parent with immunization history record and record this injection in patient's medical records.
• Instruct patient to give analgesic for local pain. Avoid giving aspirin to children.
• Inform parent or patient of schedule for vaccination program if necessary.

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Exposure to Hepatitis B Virus

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