Medication Guide App


Scientific Name(s): Pimenta dioica (L.) Merr. Family: Myrtaceae (myrtle)

Common Name(s): Allspice , pimenta , Jamaica pepper , clove pepper , pimento


Apart from use for spices and fragrance, allspice has been used traditionally for various GI complaints, rheumatism, and neuralgia. Extracts demonstrate antimicrobial properties; however, clinical studies are lacking.

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There are no clinical applications for P. dioica or clinical evidence to provide dosing recommendations.


Contraindications have not yet been identified.


GRAS (generally recognized as safe) when used as food. Ingestion in excess of amounts found in food should be avoided because safety and efficacy are unproven.


None well documented.

Adverse Reactions

Allspice can irritate mucosa. Clinical studies are lacking.


Allspice is not generally associated with toxicity, but eugenol can be toxic in high concentrations. Ingestion of extracts may produce toxicity and affect the CNS.


P. dioica is a sturdy perennial tree that grows to 13 m. It has leathery, oblong leaves and is native to the West Indies, Central America, and Mexico. Dried, full-grown but unripe fruit and leaves are used medicinally. Commercially available allspice powder consists of the whole ground, dried fruit. Synonyms include Pulmonaria officinalis Lindl., Pimenta pimenta (L.) Karst., Pimenta vulgaris Lindl., and Myrtus dioica and Myrtus pimenta . The plant should not be confused with Lippia sidoides , commonly called “alecrim-pimenta” in Brazil. 1 , 2 , 3 , 4


Allspice is used as a food flavoring, odor reminiscent of a combination of cloves, cinnamon, and nutmeg. It has also been used in cosmetics and toothpastes. Allspice has been used medicinally as a tonic, purgative, carminative, and antidiarrheal, as well as for rheumatism, neuralgia, and stomachache. 3


Allspice berries contain between 1% and 4% of a volatile oil, which contains between 60% and 80% eugenol and eugenol methyl ether (40% to 45%). The leaf oil contains more eugenol (up to 96%) and is similar in composition to clove leaf oil. Allspice oil also contains cineole, levophellandrene, caryophyllene, and palmitic acid. Enzymes released after harvesting appear to be responsible for producing many of the volatile components from chemical precursors. Small amounts of resin, tannic acid, and an acrid fixed oil are present. Other phenolic glycosides and flavonoids have been identified in the berries. Gas chromatography has been used to describe the chemical composition of the essential oil. 2 , 3 , 5 , 6 , 7

Uses and Pharmacology

Any pharmacologic activity associated with the plant is most likely caused by the presence of eugenol; however, clinical studies are lacking. 3 Antioxidant properties have been described for allspice, but studies evaluating this property in clinical applications are also lacking. 5 , 7 , 8

Antimicrobial effects
Animal data

Allspice essential oil has been evaluated for effect against nematodes and ticks. 6 , 9 Activity has also been demonstrated against a limited range of bacteria including Escherichia coli , Salmonella enterica , and Listeria monocytogenes , with possible applications in the food industry. 10 , 11 Activity appears limited against Staphylococcus aureus and E. coli toxin. 12 , 13

Clinical data

Research reveals no clinical data regarding the use of allspice for antimicrobial properties.

Other effects

A methanol extract from the plant leaves showed both prohibitory and inhibitory effects on estrogen receptors in vitro, supporting the traditional use of allspice in menopause in Costa Rica. 14

An aqueous extract of allspice reduced the growth of prostate cancer cells in a laboratory experiment possibly via androgen receptor activity. 15 , 16


The essential oil of allspice has been used at doses of 0.05 to 0.2 mL; however, there is no clinical evidence to support this dosage. 3 Traditional uses of allspice have reported 5 to 10 mL per 240 mL of water taken 3 times a day. 3


GRAS when used as food. Avoid ingestion in excess of amounts found in food because safety and efficacy are unproven. 17


None well documented. An in vitro experiment suggests allspice may upregulate cytochrome P450 3A4 activity; however, the relevance of this finding is unknown. 15

Adverse Reactions

Allspice and extracts of the plant can be irritating to mucous membranes. 2 , 3


Although allspice has not been generally associated with toxicity, eugenol can be toxic in high concentrations. Ingestion of more than 5 mL of allspice oil may induce nausea, vomiting, CNS depression, and convulsions. 18 When the oil and eugenol were applied to intact, shaved abdominal mouse skin, no percutaneous absorption was observed. 2


1. Pimenta dioica . USDA, NRCS. 2007. The PLANTS Database ( , 4 June 2011). National Plant Data Team, Greensboro, NC 27401-4901 USA.
2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs, and Cosmetics. 2nd ed. Hoboken, NJ: Wiley-Interscience; 2003.
3. Duke JA. Handbook of Medicinal Herbs . Boca Raton, FL: CRC Press; 2002.
4. Botelho MA, Bezerra Filho JG, Correa LL, et al. Effect of a novel essential oil mouthrinse without alcohol on gingivitis: a double-blinded randomized controlled trial. J Appl Oral Sci . 2007;15(3):175-180.
5. Padmakumari KP, Sasidharan I, Sreekumar MM. Composition and antioxidant activity of essential oil of pimento ( Pimenta dioica (L) Merr.) from Jamaica. Nat Prod Res . 2011;25(2):152-160.
6. Martinez-Velazquez M, Castillo-Herrera GA, Rosario-Cruz R, et al. Acaricidal effect and chemical composition of essential oils extracted from Cuminum cyminum , Pimenta dioica and Ocimum basilicum against the cattle tick Rhipicephalus ( Boophilus ) microplus (Acari: Ixodidae). Parasitol Res . 2011;108(2):481-487.
7. Kikuzaki H, Miyajima Y, Nakatani N. Phenolic glycosides from berries of Pimenta dioica . J Nat Prod . 2008;71(5):861-865.
8. Tsai PJ, Tsai TH, Yu CH, Ho SC. Evaluation of NO-suppressing activity of several Mediterranean culinary spices. Food Chem Toxicol . 2007;45(3):440-447.
9. Park IK, Kim J, Lee SG, Shin SC. Nematicidal Activity of Plant Essential Oils and Components From Ajowan ( Trachyspermum ammi ), Allspice ( Pimenta dioica ) and Litsea ( Litsea cubeba ) Essential Oils Against Pine Wood Nematode ( Bursaphelenchus Xylophilus ). J Nematol . 2007;39(3):275-279.
10. Du WX, Olsen CW, Avena-Bustillos RJ, McHugh TH, Levin CE, Friedman M. Effects of allspice, cinnamon, and clove bud essential oils in edible apple films on physical properties and antimicrobial activities. J Food Sci . 2009;74(7):M372-M378.
11. Du WX, Olsen CW, Avena-Bustillos RJ, et al. Antibacterial effects of allspice, garlic, and oregano essential oils in tomato films determined by overlay and vapor-phase methods. J Food Sci . 2009;74(7):M390-M397.
12. Masatcioglu TM, Avsar YK. Effects of flavorings, storage conditions, and storage time on survival of Staphylococcus aureus in Sürk cheese. J Food Prot . 2005;68(7):1487-1491.
13. Takemasa N, Ohnishi S, Tsuji M, Shikata T, Yokoigawa K. Screening and analysis of spices with ability to suppress verocytotoxin production by Escherichia coli O157. J Food Sci . 2009;74(8):M461-M466.
14. Doyle BJ, Frasor J, Bellows LE, et al. Estrogenic effects of herbal medicines from Costa Rica used for the management of menopausal symptoms. Menopause . 2009;16(4):748-755.
15. Lee YH, Hong SW, Jun W, et al. Anti-histone acetyltransferase activity from allspice extracts inhibits androgen receptor-dependent prostate cancer cell growth. Biosci Biotechnol Biochem . 2007;71(11):2712-2719.
16. Marzouk MS, Moharram FA, Mohamed MA, Gamal-Eldeen AM, Aboutabl EA. Anticancer and antioxidant tannins from Pimenta dioica leaves. Z Naturforsch C . 2007;62(7-8):526-536.
17. Food. Listing of Food Additive Status Part I. US Food and Drug Administration Web site. . Last updated June 7, 2011. Accessed October 3, 2011.
18. Spoerke DG. Herbal Medications . Santa Barbara, CA: Woodbridge Press: 1980.

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