Methylsufonyl-methane (MSM)
Common names: Methylsulfonyl-methane also is known as MSM and DMSO2.
Efficacy-safety rating:
●●...Ethno or other evidence of efficacy.
Safety rating:
●...No safety concerns despite wide use.What is Methylsufonyl-methane (MSM)?
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MSM is a natural chemical in green plants such as Equisetum arvense, certain algae, fruits, vegetables, and grains. It also is seen in animals (eg, the adrenal cortex of cattle, human and bovine milk, and urine). MSM is naturally occurring in fresh foods. However, it is destroyed with even moderate food processing, such as heat or dehydration.
MSM is the normal oxidation product of DMSO (dimethyl sulfoxide). Unlike DMSO, MSM is odor-free and is a dietary factor. MSM has been referred to as “crystalline DMSO.” It provides a source of sulfur for methionine.
What is Methylsufonyl-methane (MSM) used for?
Miscellaneous usesMSM is a natural chemical, which may be of some use for skin problems, GI upset, and certain cancers. MSM is also said to alleviate musculoskeletal pain, arthritis, and allergies; to boost the immune system; and to possess antimicrobial effects. MSM has been suggested for use as a food supplement.
Most of the studies have been done on animals. Human trials are needed to fully assess MSM's therapeutic benefits.
What is the dosage of Methylsufonyl-methane (MSM)?
MSM commonly is given first at a loading dose of 2 to 5 g/day, then as a maintenance dose of 50 to 200 mg/day for arthritis and other joint conditions.
Is Methylsufonyl-methane (MSM) safe?
ContraindicationsContraindications have not yet been identified.
Pregnancy/nursingInformation regarding safety and efficacy in pregnancy and lactation is lacking.
InteractionsNone well documented.
Side EffectsNo adverse reactions with MSM have been reported.
ToxicitiesNo important toxicities were noted in animal reports.
References
- Methylsulfonylmethane. Review of Natural Products. factsandcomparisons4.0 [online]. 2004. Available from Wolters Kluwer Health, Inc. Accessed April 17, 2007.
Copyright © 2006 Wolters Kluwer Health
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Compare Methylsufonyl-methane (MSM) with other medications for the treatment of:
Dietary Supplementation, Muscle Pain
