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What types of hepatitis C (HCV) does Vosevi treat?

Medically reviewed by Drugs.com. Last updated on Sep 5, 2023.

Official answer

by Drugs.com

Vosevi (sofosbuvir, velpatasvir and voxilaprevir) is FDA-approved for the treatment of adults with chronic hepatitis C virus (HCV) of two types:

  • genotype 1, 2, 3, 4, 5, or 6 infection previously treated with an NS5A inhibitor regimen, or
  • genotype 1a or 4 infection previously treated with a sofosbuvir regimen without an NS5A inhibitor.

Vosevi is supplied as tablets containing sofosbuvir 400 mg, velpatasvir 100 mg, and voxilaprevir 100 mg. The recommended course of treatment for HCV in adults without cirrhosis, or with compensated cirrhosis, is one tablet daily for 12 weeks.

Read next

Some of the main differences between hepatitis B and C are:

  • Hepatitis B virus can be prevented with a vaccine, but not hepatitis C.
  • Hepatitis B and C are different viruses, but you can have both hepatitis B and hepatitis C at the same time.
  • Over 90% of people infected with hepatitis C who have not received treatment can be cured with 8 to 12 weeks of oral medications, but treatment for hepatitis B, if needed, may be long-term or lifelong.
  • There is no cure for hepatitis B, but once you recover from acute hepatitis B, you develop antibodies that protect you from the virus for life.
Continue reading

The newest drugs for the treatment of hepatitis C include Mavyret (glecaprevir and pibrentasvir), Vosevi (sofosbuvir, velpatasvir, and voxilaprevir), and Epclusa (sofosbuvir and velpatasvir). All are FDA-approved for the treatment of chronic hepatitis C virus (HCV) genotype 1, 2, 3, 4, 5 or 6 infection without cirrhosis or with compensated cirrhosis (Child-Pugh A), as well as other uses. Continue reading

Epclusa (sofosbuvir and velpatasvir) is given as a single daily pill for 12 weeks duration. With advanced liver disease (decompensated cirrhosis, Child-Pugh B or C), it is combined with ribavirin, also for 12 weeks. If Epclusa is prescribed with ribavirin, follow your doctor’s recommendations for ribavirin dosing. Continue reading

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