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How is Leqvio injection administered?

Medically reviewed by Carmen Pope, BPharm. Last updated on Dec 9, 2022.

Official answer

by Drugs.com

Leqvio is administered subcutaneously, which means just under the skin. Your healthcare provider will sit or lie you down and then inject Leqvio just under the skin of your abdomen, upper arm, or thigh. This may cause slight pain and redness around the site of the injection. You cannot administer Leqvio yourself.

Leqvio is usually administered every 6 months (2 doses per year) after an initial course of 2 doses given 3 months apart.

References
  • Leqvio (inclisiran) Prescribing Information. FDA Access Data. https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/214012lbl.pdf
  • Leqvio (inclisiran) [Package Insert] Updated April 1, 2022. Novartis Pharmaceuticals Corporation https://www.drugs.com/pro/leqvio.html
  • What is Leqvio. Leqvio.com. https://www.leqvio.com/what-is-leqvio

Read next

Leqvio and Repatha are both injectable medicines that are used for the treatment of high cholesterol, by specifically lowering low density lipoprotein (LDL) levels. Although they both inhibit PCSK9 they work by different mechanisms. Repatha is a monoclonal antibody that binds directly to PCSK9 in the liver preventing it from binding to LDL receptors. Leqvio blocks the PCSK9 protein by interfering with the translation of PCSK9 messenger RNA. Both have the same result – and that is freeing up LDL receptors on the surface of liver cells which allows LDL cholesterol to be removed from the blood. Continue reading

The PCSK9 inhibitors are used for the treatment of high-risk patients with elevated cholesterol, especially when statins aren't adequate. They work by blocking PCSK9, leaving more receptors available to capture your "bad" cholesterol (LDL) for break down and removal from the blood. Continue reading

Leqvio may be used alone or with other medications, such as statins, to treat high cholesterol, in addition to a heart-healthy diet. But it can be prescribed without a statin if statins are not tolerated or contraindicated. Continue reading

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