Is Genvoya better than Stribild?
Yes, Genvoya was designed as a new and improved version of Stribild, it has a similar clinical effect on HIV but a better safety profile.
What is the difference between Genvoya and Stribild?
Genvoya and Stribild are both four-drug HIV medications, they have three ingredients the same
(cobicistat 150mg, elvitegravir 150mg, emtricitabine 200mg).
For the fourth ingredient:
- Genvoya has tenofovir alafenamide (TAF) 10mg and
- Stribild has tenofovir disoproxil fumerate (TDF) 300mg.
Stribild was the first of these two medicines to be approved by the FDA on 27 August 2012.
Genvoya was approved on 5 November 2015.
Why did they change tenofovir disoproxil fumerate (TDF) to tenofovir alafenamide (TAF) for Genvoya?
- Tenofovir disoproxil fumerate, which is one of the ingredients in Stribild, can have side effects of being toxic to the kidneys and can reduce bone density.
- To overcome this issue Genvoya was developed which replaced tenofovir disoproxil fumerate with tenofovir alafenamide which has improved safety for kidney and bones.
- Genvoya had the same clinical effect as Stribild but had better kidney and bone safety when compared to Stribild.
Bottom line:
- Genvoya was designed to have the same clinical effect against HIV as Stribild, but have improved renal and bone safety when compared to Stribild.
- Genvoya contains tenofovir alafenamide (TAF) 10mg with cobicistat 150mg, elvitegravir 150mg and emtricitabine 200mg
- Stribild contains tenofovir disoproxil fumarate (TDF) 300mg with cobicistat 150mg, elvitegravir 150mg and emtricitabine 200mg
References
- Tenofovir alafenamide versus tenofovir disoproxil fumarate, coformulated with elvitegravir, cobicistat, and emtricitabine, for initial treatment of HIV-1 infection: two randomised, double-blind, phase 3, non-inferiority trials: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)60616-X/fulltext
- Genvoya Medication Information: https://www.drugs.com/genvoya.html
- Stribild Medication Information: https://www.drugs.com/stribild.html
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Drug information
- Genvoya
- Stribild
- Cobicistat / elvitegravir / emtricitabine / tenofovir
- Cobicistat / elvitegravir / emtricitabine / tenofovir Alafenamide
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