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Best time to take amlodipine - day or night?

Medically reviewed by Drugs.com. Last updated on Oct 16, 2023.

Official answer

by Drugs.com

It does not matter what time of day you take amlodipine (morning or evening) but it is best to take it at the same time every day, when you are most likely to remember, for more even blood levels and therefore effectiveness.

Amlodipine is a calcium channel blocker that dilates blood vessels and improves blood flow. Amlodipine is used to treat chest pain (angina) and other conditions caused by coronary artery disease. Amlodipine is also used to treat high blood pressure.

Amlodipine may be taken with or without food.

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Swelling from amlodipine is a common, but often troublesome side effect of amlodipine with 5% to 9% of people stopping amlodipine because of it. If you develop swelling with amlodipine, tell your doctor right away because they may be able to change your blood pressure medications slightly to help reduce the swelling. Swelling caused by amlodipine does not usually respond to treatment with diuretics (such as furosemide) because it is caused by changes in capillary pressure that result in leakage into the spaces between capillaries (called the interstitial area) rather than water retention. Continue reading

Amlodipine can take more than 8 hours to start working, because it takes a long time to be absorbed. This means it is not a good choice for lowering blood pressure quickly, and other agents, such as hydralazine, clonidine, and nifedipine XL (which work within 1 to 2 hours) are preferred. Continue reading

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