Zypitamag Dosage

Important Dosage and Administration Information

• Take ZYPITAMAG orally once daily with or without food at the same time each day.
• For patients that require a high-intensity statin or are unable to achieve their LDL-C goal receiving ZYPITAMAG 4 mg daily, prescribe alternative LDL-C-lowering treatment.
• Assess LDL-C when clinically appropriate, as early as 4 weeks after initiating ZYPITAMAG, and adjust the dosage if necessary.

Recommended Dosage for Adults

• The recommended dosage range of ZYPITAMAG is 2 mg to 4 mg daily.
• The maximum recommended dosage is ZYPITAMAG 4 mg once daily.

Recommended Dosage in Patients with Renal Impairment

• The recommended starting dosage for patients with moderate and severe renal impairment (estimated glomerular filtration rate 30 – 59 mL/minute/1.73 m2 and 15 – 29 mL/minute/1.73 m2, respectively) and patients with end-stage renal disease receiving hemodialysis is pitavastatin 1 mg once daily. ZYPITAMAG is not available in a 1 mg dose; use an alternative formulation of pitavastatin for the 1 mg dose. The maximum recommended dose for these patients is ZYPITAMAG 2 mg once daily [see Use in Specific Populations (8.6)].
• There are no dosage adjustment recommendations for patients with mild renal impairment.

Dosage Adjustments Due to Drug Interactions

• In patients taking erythromycin, do not exceed pitavastatin 1 mg once daily [see Drug Interactions (7)]. ZYPITAMAG is not available in a 1 mg dose; use an alternative formulation of pitavastatin for the 1 mg dose.
• In patients taking rifampin, do not exceed ZYPITAMAG 2 mg once daily [see Drug Interactions (7)].

Pediatric use information is approved for Kowa Co Ltd’s LIVALO (pitavastatin) tablets. However, due to Kowa Co Ltd’s marketing exclusivity rights, this drug product is not labeled with that information