Vueway Dosage

2.1  Recommended Dosage

The recommended dose of Vueway for adult and pediatric patients aged 2 years and older is 0.05 mmol/kg actual body weight (equivalent to 0.1 mL/kg) administered intravenously at approximately 2 mL/sec.

2.2  Administration and Imaging Instructions

• Use aseptic technique for all handling and administration of Vueway.
• Visually inspect Vueway for particulate matter and discoloration prior to administration. Do not use the solution if any particulate matter is present or the solution is discolored.
• Do not mix with other medications because of the potential for chemical incompatibility.
• Prime intravenous line before use.
• Administer Vueway as an intravenous bolus injection, manually or by compatible power injector. The recommended injection rate is approximately 2 mL/second.
• Flush the intravenous line with 0.9% Sodium Chloride Injection, USP after the administration of Vueway.
• Contrast MRI can begin immediately following the injection of Vueway.

2.3  Directions for Use of Single-Dose Vial and Pre-filled Syringe

Vial

• Do not pierce the rubber stopper more than once.
• Aseptically draw up Vueway into a disposable syringe and use immediately.
• If solidification occurs in the vial because of exposure to the cold, bring the vial of Vueway to room temperature before use and inspect that the solution is clear, colorless to yellow without any particulate matter and discoloration.
• Discard any unused portion.

Pre-filled syringe

• Remove the tip cap of the syringe, screw the plunger rod and use immediately.
• All luer connections should be gently hand tightened without over tightening, to ensure secure connections and to prevent damage to the device.
• Pre-filled syringes must not be frozen. Frozen pre-filled syringes of Vueway should be discarded.
• Discard any unused portion.

2.4  Directions for Use of Pharmacy Bulk Package

• Do not use the Pharmacy Bulk Package for direct infusion.
• Perform the transfer of Vueway from the Pharmacy Bulk Package in an aseptic work area, such as laminar flow hood, using aseptic technique and suitable transfer device for filling empty syringes.
• Penetrate the closure only one time. Once the container closure is punctured, do not remove the Pharmacy Bulk Package from the aseptic work area.
• The Pharmacy Bulk Package is used with an appropriate transfer device for filling empty sterile syringes. Use each individual dose of Vueway promptly following withdrawal from the Pharmacy Bulk Package.
• Use the contents of the Pharmacy Bulk Package within 24 hours at room temperature after initial puncture.
• If solidification occurs in the vial because of exposure to the cold, bring the vial of Vueway to room temperature before use and inspect that the solution is clear, colorless to yellow without any particulate matter and discoloration.