Varicella Virus Vaccine Dosage

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Varicella-Zoster - Prophylaxis

Two doses of 0.5 mL subcutaneously, 4 to 8 weeks apart

Usual Pediatric Dose for Varicella-Zoster - Prophylaxis

>= 1 year to 12 years: 0.5 mL subcutaneously once.

>= 13 years: Two doses of 0.5 mL subcutaneously, 4 to 8 weeks apart

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

No adjustment recommended

Precautions

Varicella vaccine is contraindicated in patients with a history of hypersensitivity to gelatin or neomycin; patients with blood dyscrasias, leukemia, lymphomas, or any malignant neoplasms of the bone marrow or lymphatic system; patients receiving immunosuppressive treatment; patients with primary, acquired, or congenital immunodeficiency; patients with active untreated tuberculosis, any febrile respiratory illness, or active febrile infections.

The duration of protection from chickenpox is unknown. It is not known whether the vaccine is effective for postexposure prophylaxis.

Vaccination should be deferred for at least 5 months after blood or plasma transfusions, or administration of immune globulin or varicella zoster immune globulin. Administration of any immune globulin should be deferred for at least 2 months after varicella vaccination, unless the risk outweighs benefit.

The use of salicylates during natural chickenpox infections has been associated Reye's Syndrome; therefore, vaccinees should be advised to avoid salicylates for 6 weeks after vaccination.

Intravascular administration should be avoided.

Viral transmission has rarely been reported between vaccinees who develop a varicella-like rash and healthy contacts. Therefore, vaccinees should avoid contact with high-risk persons (e.g., immunocompromised individuals, pregnant women without a history of chickenpox, newborn infants of mothers without a history of chickenpox) for up to 6 weeks.

Vaccination should be deferred in patients with a family history of congenital or hereditary immunodeficiency until the patient's immune system function has been evaluated.

The safety and efficacy of varicella vaccine have not been established in children and young adults with HIV and without evidence of immunosuppression.

Dialysis

No adjustment recommended

Other Comments

Varicella vaccine should be kept frozen before reconstitution to maintain potency. It may be kept in the refrigerator for not more than 72 hours. The diluent may be kept refrigerated or at room temperature. Reconstituted vaccine should be used immediately, or discarded after 30 minutes.

Adverse reactions should be reported to the U.S. Department of Health and Human Services Vaccine Adverse Event Reporting System. Reporting forms and information regarding the completion of the form can be obtained at 1-800-822-7967 (USA).

The ACIP (Advisory Committee on Immunization Practices) recommends that live-virus vaccines not administered on the same day should be administered at least 30 days apart. There is concern that the vaccine given first could interfere with response to the vaccine given second. ACIP recommends that if two live parenteral vaccines are given less than 28 days apart, the vaccine given second should not be counted as valid and should be repeated at least 4 weeks later.

Hide
(web5)