Hydrochlorothiazide/Propranolol Dosage
This dosage information may not include all the information needed to use Hydrochlorothiazide/Propranolol safely and effectively. See additional information for Hydrochlorothiazide/Propranolol.
The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Hypertension
Initial dose: 1 tablet of (hydrochlorothiazide-propranolol 25 mg/40 mg) orally once a day or
1 capsule of (hydrochlorothiazide-propranolol LA 50 mg/48 mg) orally once a day.
Determine dosage by individual titration.
Maintenance dose: Titrate as needed to 1 tablet of (hydrochlorothiazide-propranolol 25 mg/40 mg) orally twice a day or 1 capsule of (hydrochlorothiazide-propranolol LA 50 mg/160 mg) orally once a day.
Renal Dose Adjustments
Hydrochlorothiazide is generally not effective in patients with creatinine clearance less than 25 mL/min. Thiazide diuretics should be used with caution in patients with severe renal disease.
Liver Dose Adjustments
Thiazides should be used with caution in patients with impaired hepatic function. Patients with cirrhosis may show a marked heart rate reduction with conventional doses of propranolol. A low initial dose is recommended.
Dose Adjustments
When necessary, another antihypertensive agent may be added gradually beginning with 50% of the usual recommended starting dose to avoid an excessive fall in blood pressure.
Precautions
Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).
Dialysis
Propranolol is not significantly dialyzable.
Other Comments
For doses of propranolol greater than 160 mg the combination products are not appropriate, because their use would lead to an excessive dose of the thiazide component.
