Dutasteride / Tamsulosin Dosage

Medically reviewed by Drugs.com. Last updated on Jun 5, 2023.

Usual Adult Dose for Benign Prostatic Hyperplasia

Dutasteride 0.5 mg-Tamsulosin 0.4 mg orally once a day approximately 30 minutes after the same meal each day

Use: Treatment of symptomatic benign prostatic hyperplasia (BPH) in men with an enlarged prostate.

Renal Dose Adjustments

CrCl 10 mL/min or more: No adjustment recommended
CrCl less than 10 mL/min: Data not available

Liver Dose Adjustments

Mild to moderate liver dysfunction: No adjustment recommended
Severe liver dysfunction: Data not available

Precautions

CONTRAINDICATIONS:

• Previously demonstrated, clinically significant hypersensitivity (e.g., serious skin reactions, angioedema, urticaria, pruritus, respiratory symptoms) to either active component, any of the ingredients, or other 5-alpha-reductase inhibitors
• Pregnancy
• Women of childbearing potential
• Pediatric patients

Safety and efficacy have not been established in pediatric patients.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice: This drug should be swallowed whole and not chewed or opened.

General: This drug should not be handled by women who are pregnant or who could become pregnant.

Monitoring:

• Genitourinary: Prostate-specific antigen (PSA) (to interpret serial PSA values, baseline PSA should be established at least 3 months after starting treatment and PSA monitored periodically thereafter)

Patient advice:

• Advise patients starting this drug to avoid situations where syncope could result in injury.
• Advise patients to tell their ophthalmologists that they take or have taken this drug.
• Advise patients regarding the possibility and seriousness of priapism.
• Advise patients to avoid blood donation for at least 6 months after their final dose.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer