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Clenpiq Dosage

Generic name: SODIUM PICOSULFATE 10mg in 175mL, MAGNESIUM OXIDE 3.5g in 175mL, ANHYDROUS CITRIC ACID 12g in 175mL
Dosage form: oral solution
Drug class: Laxatives

Medically reviewed by Drugs.com. Last updated on Sep 5, 2023.

Important Administration Instructions

  • ​Correct fluid and electrolyte abnormalities before administration of CLENPIQ [see Warnings and Precautions (5.1)].
  • ​CLENPIQ is ready to drink. It is a clear solution with possible presence of visible particles and it does not need to be diluted prior to administration. One bottle of CLENPIQ is equivalent to one dose.
  • ​Two doses of CLENPIQ are required for a complete preparation for colonoscopy as a Split-Dose regimen.
  • ​The Split-Dose method consists of two separate doses: the first dose during the evening before the colonoscopy and the second dose the next day, during the morning prior to the colonoscopy [see Dosage and Administration (2.2)].
  • ​Consume five or more 8-ounce cups of clear liquids after the first dose and four or more 8-ounce cups of clear liquids after the second dose [see Dosage and Administration (2.2)].
  • ​Consume a variety of clear liquids. Clear liquids should include balanced electrolyte solution [see Warnings and Precautions (5.1, 5.5)]. Additional clear liquids, other than water, include black coffee or tea, plain jello, clear broth or bouillon, clear juices without pulp, ginger ale and other sodas, and frozen juice bars. Do not drink anything colored red or purple.
  • ​Consume only clear liquids (no solid food) on the day before colonoscopy and until after the colonoscopy.
  • ​Do not eat solid food or dairy and do not drink anything colored red or purple.
  • ​Do not drink alcohol.
  • ​Stop consumption of all liquids at least 2 hours before the colonoscopy.
  • ​Do not take other laxatives while taking CLENPIQ.
  • ​Administer oral medications at least one hour before starting each dose of CLENPIQ.
  • ​If taking tetracycline or fluoroquinolone antibiotics, iron, digoxin, chlorpromazine, or penicillamine, take these medications at least 2 hours before and not less than 6 hours after administration of CLENPIQ.

Split-Dose Dosage Regimen

The recommended dosage in adults and pediatric patients 9 years of age and older is shown below. Instruct patients to take two separate doses in conjunction with liquids, as follows:

Dose 1 – On the day before colonoscopy:

  • ​Instruct patients to consume only clear liquids (no solid food or dairy) on the day before the colonoscopy up until 2 hours before the time of the colonoscopy.
  • ​Take the first dose (1 bottle) of CLENPIQ during the evening before the colonoscopy (e.g., 5:00 PM to 9:00 PM).
  • ​Consume at least five 8-ounce cups (cup provided) of clear liquids after the CLENPIQ dose over the next 5 hours.
  • ​If severe bloating, distention, or abdominal pain occurs, following the first dose, delay the second dose until the symptoms resolve.

Dose 2 – Next morning on the day of colonoscopy (start approximately 5 hours prior to colonoscopy):

  • ​Continue to consume only clear liquids (no solid food or dairy).
  • ​Take the second dose (the second bottle) of CLENPIQ.
  • ​Consume four or more 8-ounce cups (cup provided) of clear liquids after the CLENPIQ dose and up to 2 hours before the colonoscopy.

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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