Cenegermin Ophthalmic Dosage

Applies to the following strengths: bkbj 0.002%

Usual Adult Dose for Keratitis

Instill 1 drop in affected eye(s) 6 times per day at 2-hour intervals
Duration of therapy: 8 weeks

Comments:

If more than 1 topical ophthalmic product is being used, administer eye drops at least 15 minutes apart to avoid diluting products.
This drug should be administered 15 minutes prior to any eye ointment, gel, or other viscous eye drop.
Consult other comments for specific administration advice.

Use: For the treatment of neurotrophic keratitis.

2 years or older:
Instill 1 drop in affected eye(s) 6 times per day at 2-hour intervals
Duration of therapy: 8 weeks

Comments:

If more than 1 topical ophthalmic product is being used, administer eye drops at least 15 minutes apart to avoid diluting products.
This drug should be administered 15 minutes prior to any eye ointment, gel, or other viscous eye drop.
Consult other comments for specific administration advice.

Use: For the treatment of neurotrophic keratitis.

No adjustment recommended

No adjustment recommended

CONTRAINDICATIONS:

Safety and efficacy have not been established in patients younger than 2 years.

Consult WARNINGS section for additional precautions.

Data not available

Administration advice:

For ocular use only
Remove contact lenses before instilling drops; may reinsert lenses 15 minutes following administration
If more than 1 topical ophthalmic product is being administered, separate administration by at least 15 minutes to avoid diluting products; administer this drug 15 minutes prior to any eye ointment, gel, or other viscous eye drops
Supplied in a weekly carton containing 7 multiple-dose vials in an insulated pack with 8 vial adapters, 45 pipettes, 45 sterile disinfectant wipes, and a dose card; patient should be instructed to refrigerate weekly carton within 5 hours of receiving from pharmacy
If treatment is started immediately, it will be necessary to wait until the first vial is thawed (carton is stored in freezer at the pharmacy; thawing may take up to 30 minutes at room temperature); do not shake vial
Follow instructions (steps 1 thru 19) included in Patient Information/Instructions for Use pamphlet
To ensure accurate dosing, patient should consider setting an alarm as a reminder for dosing

Missed dose: If a dose is missed, continue treatment at next scheduled administration

Storage requirements:

Prior to dispensing from pharmacy: Store in the freezer at or below -4F (-20C)
Dispense weekly carton in the insulated pack in the Delivery System Kit
Following dispensing: Weekly carton should be stored in the refrigerator (36F to 46F [2C to 8C]) within 5 hours of removing from freezer; may be stored refrigerated for up to 14 days
Open vials should be stored in the original carton in the refrigerator or at room temperature (up to 77F [25C]); unused portion of open vial should be discarded after 12 hours
Do not refreeze; do not shake

Patient advice:

Read the US FDA-approved patient labeling (Patient Information and Instructions for Use).
Vinson may be blurred for a short time after using this drug; if this happens, do not drive or operate hazardous machinery until vision clears.