Antivenin (Micrurus Fulvius) Dosage

Usual Adult Dose for Venomous Snake Bite

Average dose: 3 to 5 vials

• Dose depends on response to treatment

Comments:

• Each reconstituted vial can neutralize approximately 2 mg Micrurus fulvius venom (approximately 250 mouse LD 50 [lethal dose]).

Use: Only for treatment of envenomation by North American coral snake (Micrurus, including eastern and Texas varieties)

Usual Pediatric Dose for Venomous Snake Bite

Adolescents: Average dose: to 5 vials

• Dose depends on response to treatment

Small children: Dose may be decreased, depending on response to treatment

Comments:

• Each reconstituted vial can neutralize approximately 2 mg Micrurus fulvius venom (approximately 250 mouse LD 50 [lethal dose]).

Use: Only for treatment of envenomation by North American coral snake (Micrurus, including eastern and Texas varieties)

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

CONTRAINDICATIONS:

• Do not administer prophylactically to asymptomatic patients
• Hypersensitivity to horse serum, unless benefits outweigh risks and anaphylaxis management is readily available

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:

• For intravenous administration only.
• The manufacturer product information should be consulted for detailed administration instructions.

Storage requirements:

• Refrigerate; do not freeze

Reconstitution/preparation techniques:

• Reconstitute each vial with 10 mL sterile water for injection
• Do not shake
• Swirl for 1 minute every 5 minutes until complete dissolution
• Complete reconstitution takes at least 30 minutes
• Use within 4 hours of reconstitution.

IV compatibility:

• Sodium chloride

General:

• Determine if the patient is hypersensitive to horse serum.

Patient advice:

• Patients should contact a healthcare provider immediately if signs of delayed allergic reaction or serum sickness appear within 2 weeks of hospital discharge.
• Signs include rash, itching, joint pain, fever, lymphadenopathy, and malaise.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer