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raxibacumab (Intravenous route)

rax-i-BAK-ue-mab

Commonly used brand name(s)

In the U.S.

  • Raxibacumab

Available Dosage Forms:

  • Solution

Therapeutic Class: Antitoxin

Pharmacologic Class: Monoclonal Antibody

Uses For raxibacumab

Raxibacumab injection is given with antibiotic medicines to treat inhalational anthrax. It is also used to prevent inhalational anthrax when there are no other available treatments.

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Anthrax is a serious disease that may cause death. It is spread by touching or eating something that is infected with the anthrax germ, such as animals, or by breathing in the anthrax germ.

raxibacumab is to be given only by or under the direct supervision of your doctor.

Before Using raxibacumab

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For raxibacumab, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to raxibacumab or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of raxibacumab injection in the pediatric population.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of raxibacumab injection in the elderly.

Pregnancy

Pregnancy Category Explanation
All Trimesters B Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Proper Use of raxibacumab

A nurse or other trained health professional will give you raxibacumab. The medicine is given through a needle placed in a vein.

The medicine must be given slowly, so your IV tube will need to stay in place for 2 hours and 15 minutes. You may also receive medicines beforehand (e.g., diphenhydramine, Benadryl®) to help prevent possible allergic reactions to the injection.

raxibacumab comes with a patient information leaflet. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Precautions While Using raxibacumab

Your doctor will check your progress closely while you are receiving raxibacumab. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it.

raxibacumab may cause skin reactions, such as a rash or itching, while you are receiving the injection or within 24 hours after you receive it. Check with your doctor or nurse right away if you have any of these symptoms.

raxibacumab Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Less common
  • Itching skin
  • reddened skin
  • skin rash
Less common or rare
  • dizziness
  • fainting
  • fast, irregular, pounding, or racing heartbeat or pulse
  • feeling of warmth
  • redness of the face, neck, arms, and occasionally, upper chest
  • unusual tiredness or weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Pain in the arms or legs
  • sleepiness or unusual drowsiness
Less common or rare
  • dizziness or lightheadedness
  • muscle spasms
  • pain at the injection site
  • sensation of spinning

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

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