ALS (Amyotrophic Lateral Sclerosis)
Medically reviewed by Drugs.com. Last updated on May 6, 2024.
What is amyotrophic lateral sclerosis (ALS)?
ALS is a condition that damages the cells of your motor nerves. The motor nerves direct your muscles to move. These muscles gradually weaken and waste away. Over time, ALS may lead to total paralysis, including the muscles for breathing. It is a progressive disease that becomes fatal over time. ALS is also called Lou Gehrig disease.
What increases my risk for ALS?
The cause of ALS is not known. Any of the following can increase your risk:
- An autoimmune disorder that causes your immune system to attack its own nerves
- A chemical imbalance, such as too much glutamate (a chemical that sends signals from one nerve to another)
- Exposure to chemicals such as fertilizers and pesticides used in gardening or lawn care
- A family history of thyroid disease or an autoimmune disorder
- An infection that damages the motor neurons
What are the signs and symptoms of ALS?
The early symptoms of ALS include muscle weakness, tightness or stiffness, and cramps. These symptoms occur in a leg or arm. Early symptoms may instead include slurred or nasal speech, or difficulty chewing or swallowing. Symptoms worsen and spread to other parts of your body over time. You may also have any of the following:
- A weak hand grip, dropping things often, or trouble buttoning clothes or writing
- Tiredness more than usual, dragging one leg, or tripping when you walk
- Arm or leg jerks while resting
- Muscle twitching
- Drooling or trouble breathing
How is ALS diagnosed?
ALS cannot be diagnosed with one test. Your healthcare providers may do several tests to see if another condition is causing your symptoms. You may need any of the following tests:
- An electromyography (EMG) measures the electrical activity in the nerves that control your muscles.
- A nerve conduction velocity test measures the nerve impulses that travel between the spinal cord and muscles.
- A lumbar puncture, or spinal tap, may be used to check glutamate levels. Your healthcare provider will take a sample of spinal fluid to be tested.
- Magnetic resonance imaging (MRI) pictures of your brain may show other problems that may be causing your symptoms. You will need to lie still during this test. The MRI machine contains a powerful magnet. Do not enter the MRI room with anything metal. Metal can cause serious injury. Tell the healthcare provider if you have any metal in or on your body.
How is ALS treated?
ALS cannot be cured. Treatment focuses on trying to ease the symptoms and slow the rate that the disease progresses.
- Medicines may be given to reduce the damage to the motor neurons by decreasing the release of glutamate. You may also be given medicines to ease muscle cramps, fatigue, and excessive saliva or mucus.
- A rehabilitation program may include physical, breathing, and speech exercises.
Treatment options
The following list of medications are related to or used in the treatment of this condition.
What should I tell my family and friends?
Make your wishes about your care and quality of life known. You may need to speak to a social worker to know all of your options. Speak to family members about your wishes. Write them down. You can change your mind any time during the process.
Where can I find more information?
- ALS Association
1275 K Street NW, Suite 250
Washington , DC 20005
Phone: 1- 202 - 407-8580
Web Address: alsa.org
Call your local emergency number (911 in the US) or have someone call if:
- You have severe chest pain.
- You suddenly have trouble breathing.
When should I call my doctor or neurologist?
- You have a fever.
- You have chills, a cough, or feel weak and achy.
- You are depressed and feel you cannot cope with your condition.
- You have questions or concerns about your condition or care.
Care Agreement
You have the right to help plan your care. Learn about your health condition and how it may be treated. Discuss treatment options with your healthcare providers to decide what care you want to receive. You always have the right to refuse treatment. The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.© Copyright Merative 2024 Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.
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